Cargando…
Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran
BACKGROUND: This study is performed to reveal most common species and subspecies of leptospires that are main causes of human leptospirosis in Guilan, Northern Province of Iran. METHODS: We performed IgM-ELISA and MAT on 282 blood samples from patients who attended to 3 hospitals in the flat area of...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481722/ https://www.ncbi.nlm.nih.gov/pubmed/23113063 |
_version_ | 1782247779810148352 |
---|---|
author | Honarmand, HR Eshraghi, SS |
author_facet | Honarmand, HR Eshraghi, SS |
author_sort | Honarmand, HR |
collection | PubMed |
description | BACKGROUND: This study is performed to reveal most common species and subspecies of leptospires that are main causes of human leptospirosis in Guilan, Northern Province of Iran. METHODS: We performed IgM-ELISA and MAT on 282 blood samples from patients who attended to 3 hospitals in the flat area of Guilan Province with clinical symptoms consisted with leptospirosis. All specimens with titers ≥ 160 against at least one pathogenic strain in MAT and with titers ≥160 in IgM-ELISA were regarded confirmed positive cases indicative acute disease. For any confirmed positive cases, we determined the strains, which had the highest titer to determine the frequency of most common serovars and serogroups. RESULTS: Seventy of 282 sera had titers ≥160 against at least one pathogenic strain in MAT and titers ≥ 160 in IgM-ELISA. We determined frequency of common causative serogroups which had highest titers in 70 positive cases and only cases which had high titers in MAT and in IgM-ELISA were selected which is a reliable criterion to detect acute disease and to determine causative serogroup. CONCLUSION: Nine serogroups including sejroe, grippotyphosa, mini, ictero haemorrhagiae, celledoni, autumnalis, cynopteri, pomona, and javanica were more responsible of acute leptospirosis in Guilan. |
format | Online Article Text |
id | pubmed-3481722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-34817222012-10-30 Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran Honarmand, HR Eshraghi, SS Iran J Public Health Original Article BACKGROUND: This study is performed to reveal most common species and subspecies of leptospires that are main causes of human leptospirosis in Guilan, Northern Province of Iran. METHODS: We performed IgM-ELISA and MAT on 282 blood samples from patients who attended to 3 hospitals in the flat area of Guilan Province with clinical symptoms consisted with leptospirosis. All specimens with titers ≥ 160 against at least one pathogenic strain in MAT and with titers ≥160 in IgM-ELISA were regarded confirmed positive cases indicative acute disease. For any confirmed positive cases, we determined the strains, which had the highest titer to determine the frequency of most common serovars and serogroups. RESULTS: Seventy of 282 sera had titers ≥160 against at least one pathogenic strain in MAT and titers ≥ 160 in IgM-ELISA. We determined frequency of common causative serogroups which had highest titers in 70 positive cases and only cases which had high titers in MAT and in IgM-ELISA were selected which is a reliable criterion to detect acute disease and to determine causative serogroup. CONCLUSION: Nine serogroups including sejroe, grippotyphosa, mini, ictero haemorrhagiae, celledoni, autumnalis, cynopteri, pomona, and javanica were more responsible of acute leptospirosis in Guilan. Tehran University of Medical Sciences 2011-03-31 /pmc/articles/PMC3481722/ /pubmed/23113063 Text en Copyright © Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Honarmand, HR Eshraghi, SS Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran |
title | Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran |
title_full | Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran |
title_fullStr | Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran |
title_full_unstemmed | Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran |
title_short | Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran |
title_sort | detection of leptospires serogroups, which are common causes of human acute leptospirosis in guilan, northern iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481722/ https://www.ncbi.nlm.nih.gov/pubmed/23113063 |
work_keys_str_mv | AT honarmandhr detectionofleptospiresserogroupswhicharecommoncausesofhumanacuteleptospirosisinguilannortherniran AT eshraghiss detectionofleptospiresserogroupswhicharecommoncausesofhumanacuteleptospirosisinguilannortherniran |