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Endothelin-1 in systemic sclerosis
INTRODUCTION: Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and organ damage. Endothelin-1 (ET-1) plays a role in skin fibrosis. The aim of this study was survey and comparison of ET-1 level in Systemic Sclerosis (SSc) patients with and withou...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481917/ https://www.ncbi.nlm.nih.gov/pubmed/23130253 http://dx.doi.org/10.4103/2229-5178.93484 |
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author | Aghaei, Mehrdad Gharibdost, Farhad Zayeni, Habib Akhlaghi, Maryam Sedighi, Sima Rostamian, Abduo Rahman Aghdami, Naser Shojaa, Mahdieh |
author_facet | Aghaei, Mehrdad Gharibdost, Farhad Zayeni, Habib Akhlaghi, Maryam Sedighi, Sima Rostamian, Abduo Rahman Aghdami, Naser Shojaa, Mahdieh |
author_sort | Aghaei, Mehrdad |
collection | PubMed |
description | INTRODUCTION: Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and organ damage. Endothelin-1 (ET-1) plays a role in skin fibrosis. The aim of this study was survey and comparison of ET-1 level in Systemic Sclerosis (SSc) patients with and without digital ulcer. MATERIAL AND METHODS: A cross-sectional analytical study conducted among the 95 patients with scleroderma in 2006 who were referred to the Rheumatology clinic in Shariati hospital of Tehran. The questionnaire was completed for every patient. Plasma level of endothelin-1 was also measured in all of them. The data was analyzed using SPSS software and statistical tests. RESULTS: The result indicated, relationship among digital ulcers and digital pitting scars with plasma level of ET-1 were significant (P value < 0.05). We could not find any significant relationship between age and plasma level of ET-1. CONCLUSION: These data indicate plasma level of ET-1 in scleroderma patients with digital ulcer was higher than patients without digital ulcer. Thus, increase in plasma level of ET-1 could be effective in vascular damage, fibrosis, and skin thickness. |
format | Online Article Text |
id | pubmed-3481917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34819172012-11-05 Endothelin-1 in systemic sclerosis Aghaei, Mehrdad Gharibdost, Farhad Zayeni, Habib Akhlaghi, Maryam Sedighi, Sima Rostamian, Abduo Rahman Aghdami, Naser Shojaa, Mahdieh Indian Dermatol Online J Original Article INTRODUCTION: Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and organ damage. Endothelin-1 (ET-1) plays a role in skin fibrosis. The aim of this study was survey and comparison of ET-1 level in Systemic Sclerosis (SSc) patients with and without digital ulcer. MATERIAL AND METHODS: A cross-sectional analytical study conducted among the 95 patients with scleroderma in 2006 who were referred to the Rheumatology clinic in Shariati hospital of Tehran. The questionnaire was completed for every patient. Plasma level of endothelin-1 was also measured in all of them. The data was analyzed using SPSS software and statistical tests. RESULTS: The result indicated, relationship among digital ulcers and digital pitting scars with plasma level of ET-1 were significant (P value < 0.05). We could not find any significant relationship between age and plasma level of ET-1. CONCLUSION: These data indicate plasma level of ET-1 in scleroderma patients with digital ulcer was higher than patients without digital ulcer. Thus, increase in plasma level of ET-1 could be effective in vascular damage, fibrosis, and skin thickness. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3481917/ /pubmed/23130253 http://dx.doi.org/10.4103/2229-5178.93484 Text en Copyright: © Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Aghaei, Mehrdad Gharibdost, Farhad Zayeni, Habib Akhlaghi, Maryam Sedighi, Sima Rostamian, Abduo Rahman Aghdami, Naser Shojaa, Mahdieh Endothelin-1 in systemic sclerosis |
title | Endothelin-1 in systemic sclerosis |
title_full | Endothelin-1 in systemic sclerosis |
title_fullStr | Endothelin-1 in systemic sclerosis |
title_full_unstemmed | Endothelin-1 in systemic sclerosis |
title_short | Endothelin-1 in systemic sclerosis |
title_sort | endothelin-1 in systemic sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481917/ https://www.ncbi.nlm.nih.gov/pubmed/23130253 http://dx.doi.org/10.4103/2229-5178.93484 |
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