Cargando…
Successful Treatment of Cryoglobulinaemia with Rituximab
Cryoglobulinaemia is a systemic inflammatory condition characterised by immune complex-mediated small-to-medium-sized vasculitis. It has a wide variety of presentations ranging from bruising, neuropathy, and hepatosplenomegaly to acute renal failure. Mixed cryoglobulinaemia is the most common type a...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482085/ https://www.ncbi.nlm.nih.gov/pubmed/23197959 http://dx.doi.org/10.1159/000339400 |
_version_ | 1782247832475926528 |
---|---|
author | Choudhry, M. Rao, N. Juneja, R. |
author_facet | Choudhry, M. Rao, N. Juneja, R. |
author_sort | Choudhry, M. |
collection | PubMed |
description | Cryoglobulinaemia is a systemic inflammatory condition characterised by immune complex-mediated small-to-medium-sized vasculitis. It has a wide variety of presentations ranging from bruising, neuropathy, and hepatosplenomegaly to acute renal failure. Mixed cryoglobulinaemia is the most common type and is strongly associated with hepatitis C. Management approaches include use of cyclophosphamide, prednisolone, and plasmapheresis, with differing views on alternative treatments in resistant cases. Rituximab has emerged as an attractive option in resistant cases on account of its potent immunosuppressive effects on B cells. We describe a case of type 2 mixed cryoglobulinaemia in association with non-Hodgkin's lymphoma resistant to standard treatments which responded well to rituximab. This case is remarkable as mixed cryoglobulinaemia associated with non-Hodgkin's lymphoma presenting with nephritis is unusual, and, contrary to the high rate of recurrence in lymphoma-related cryoglobulinaemia, our patient has not shown any recurrence over 24 months. This highlights an alternative treatment modality which can be used in patients not responsive to existing managements for this condition with benefits of minimal side effects and no oncogenetic potential. |
format | Online Article Text |
id | pubmed-3482085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-34820852012-11-29 Successful Treatment of Cryoglobulinaemia with Rituximab Choudhry, M. Rao, N. Juneja, R. Case Rep Nephrol Urol Published: June, 2012 Cryoglobulinaemia is a systemic inflammatory condition characterised by immune complex-mediated small-to-medium-sized vasculitis. It has a wide variety of presentations ranging from bruising, neuropathy, and hepatosplenomegaly to acute renal failure. Mixed cryoglobulinaemia is the most common type and is strongly associated with hepatitis C. Management approaches include use of cyclophosphamide, prednisolone, and plasmapheresis, with differing views on alternative treatments in resistant cases. Rituximab has emerged as an attractive option in resistant cases on account of its potent immunosuppressive effects on B cells. We describe a case of type 2 mixed cryoglobulinaemia in association with non-Hodgkin's lymphoma resistant to standard treatments which responded well to rituximab. This case is remarkable as mixed cryoglobulinaemia associated with non-Hodgkin's lymphoma presenting with nephritis is unusual, and, contrary to the high rate of recurrence in lymphoma-related cryoglobulinaemia, our patient has not shown any recurrence over 24 months. This highlights an alternative treatment modality which can be used in patients not responsive to existing managements for this condition with benefits of minimal side effects and no oncogenetic potential. S. Karger AG 2012-06-14 /pmc/articles/PMC3482085/ /pubmed/23197959 http://dx.doi.org/10.1159/000339400 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published: June, 2012 Choudhry, M. Rao, N. Juneja, R. Successful Treatment of Cryoglobulinaemia with Rituximab |
title | Successful Treatment of Cryoglobulinaemia with Rituximab |
title_full | Successful Treatment of Cryoglobulinaemia with Rituximab |
title_fullStr | Successful Treatment of Cryoglobulinaemia with Rituximab |
title_full_unstemmed | Successful Treatment of Cryoglobulinaemia with Rituximab |
title_short | Successful Treatment of Cryoglobulinaemia with Rituximab |
title_sort | successful treatment of cryoglobulinaemia with rituximab |
topic | Published: June, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482085/ https://www.ncbi.nlm.nih.gov/pubmed/23197959 http://dx.doi.org/10.1159/000339400 |
work_keys_str_mv | AT choudhrym successfultreatmentofcryoglobulinaemiawithrituximab AT raon successfultreatmentofcryoglobulinaemiawithrituximab AT junejar successfultreatmentofcryoglobulinaemiawithrituximab |