Age-Dependent Changes in the Sphingolipid Composition of Mouse CD4(+) T Cell Membranes and Immune Synapses Implicate Glucosylceramides in Age-Related T Cell Dysfunction

To determine whether changes in sphingolipid composition are associated with age-related immune dysfunction, we analyzed the core sphingolipidome (i.e., all of the metabolites through the first headgroup additions) of young and aged CD4(+) T cells. Since sphingolipids influence the biophysical prope...

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Detalles Bibliográficos
Autores principales: Molano, Alberto, Huang, Zhaofeng, Marko, Melissa G., Azzi, Angelo, Wu, Dayong, Wang, Elaine, Kelly, Samuel L., Merrill, Alfred H., Bunnell, Stephen C., Meydani, Simin Nikbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482221/
https://www.ncbi.nlm.nih.gov/pubmed/23110086
http://dx.doi.org/10.1371/journal.pone.0047650

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