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Crystal structure of the multidrug transporter P-glycoprotein from C. elegans

P-glycoprotein (P-gp) is an ATP-binding cassette (ABC) transporter that confers multidrug resistance in cancer cells(1,2). It also affects the absorption, distribution, and clearance of cancer-unrelated drugs and xenobiotics. For these reasons, the structure and function of P-gp have been studied ex...

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Detalles Bibliográficos
Autores principales:	Jin, Mi Sun, Oldham, Michael L., Zhang, Qiuju, Chen, Jue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482266/ https://www.ncbi.nlm.nih.gov/pubmed/23000902 http://dx.doi.org/10.1038/nature11448

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