In-vitro inhibition of IFNγ(+) iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function

BACKGROUND: IFNγ-producing CD4(+)CD25(+)Foxp3(+) PBL represent a subtype of iTreg that are associated with good long-term graft outcome in renal transplant recipients and suppress alloresponses in-vitro. To study the mechanism of immunosuppression, we attempted to block cell surface receptors and th...

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Detalles Bibliográficos
Autores principales: Daniel, Volker, Sadeghi, Mahmoud, Wang, Haihao, Opelz, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482559/
https://www.ncbi.nlm.nih.gov/pubmed/22905732
http://dx.doi.org/10.1186/1471-2172-13-47

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482559/
https://www.ncbi.nlm.nih.gov/pubmed/22905732
http://dx.doi.org/10.1186/1471-2172-13-47

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