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In-vitro inhibition of IFNγ(+) iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function
BACKGROUND: IFNγ-producing CD4(+)CD25(+)Foxp3(+) PBL represent a subtype of iTreg that are associated with good long-term graft outcome in renal transplant recipients and suppress alloresponses in-vitro. To study the mechanism of immunosuppression, we attempted to block cell surface receptors and th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482559/ https://www.ncbi.nlm.nih.gov/pubmed/22905732 http://dx.doi.org/10.1186/1471-2172-13-47 |