Cargando…

Molecular Biology of Gallbladder Cancer: Potential Clinical Implications

Gallbladder cancer (GBC) is a common malignancy of the biliary tract and involves the changes in multiple oncogenes and multiple genetic genes. Since over the past decade there has been an advance in the knowledge of the genetic basis of cancer, mainly as a result of the rapid progression of molecul...

Descripción completa

Detalles Bibliográficos
Autor principal: Andrén-Sandberg, Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482772/
https://www.ncbi.nlm.nih.gov/pubmed/23112962
http://dx.doi.org/10.4103/1947-2714.101979
_version_ 1782247907987030016
author Andrén-Sandberg, Åke
author_facet Andrén-Sandberg, Åke
author_sort Andrén-Sandberg, Åke
collection PubMed
description Gallbladder cancer (GBC) is a common malignancy of the biliary tract and involves the changes in multiple oncogenes and multiple genetic genes. Since over the past decade there has been an advance in the knowledge of the genetic basis of cancer, mainly as a result of the rapid progression of molecular technology; however, conventional therapeutic approaches have not had much impact on the course of this aggressive neoplasm. Knowledge of the molecular biology of GBC is rapidly growing. Genetic alterations in GBC include adenosine triphosphate-binding cassette transporter ABCG8, membrane-bound enzyme ADAM-17 of multi-functional gene family, and other genes including p53, COX2, XPC, and RASSF1A. The advances in molecular biology have potential implications for the detection of this disease, using Synuclein-gamma, Syndecan-1, glycoprotein 72 (TAG-72), tumor endothelial marker 8 protein (TEM8) and TNF-alpha. The use of these molecular diagnostic methods is of clinical importance for the gene replacement therapy, genetic prodrug activation therapy, and antisense immunology technology for the treatment of malignancy. The author reviewed recent publications on PubMed, and summarized molecular biology of GBC, with an emphasis on features of potential clinical implications for diagnosis and management.
format Online
Article
Text
id pubmed-3482772
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-34827722012-10-30 Molecular Biology of Gallbladder Cancer: Potential Clinical Implications Andrén-Sandberg, Åke N Am J Med Sci Review Article Gallbladder cancer (GBC) is a common malignancy of the biliary tract and involves the changes in multiple oncogenes and multiple genetic genes. Since over the past decade there has been an advance in the knowledge of the genetic basis of cancer, mainly as a result of the rapid progression of molecular technology; however, conventional therapeutic approaches have not had much impact on the course of this aggressive neoplasm. Knowledge of the molecular biology of GBC is rapidly growing. Genetic alterations in GBC include adenosine triphosphate-binding cassette transporter ABCG8, membrane-bound enzyme ADAM-17 of multi-functional gene family, and other genes including p53, COX2, XPC, and RASSF1A. The advances in molecular biology have potential implications for the detection of this disease, using Synuclein-gamma, Syndecan-1, glycoprotein 72 (TAG-72), tumor endothelial marker 8 protein (TEM8) and TNF-alpha. The use of these molecular diagnostic methods is of clinical importance for the gene replacement therapy, genetic prodrug activation therapy, and antisense immunology technology for the treatment of malignancy. The author reviewed recent publications on PubMed, and summarized molecular biology of GBC, with an emphasis on features of potential clinical implications for diagnosis and management. Medknow Publications & Media Pvt Ltd 2012-10 /pmc/articles/PMC3482772/ /pubmed/23112962 http://dx.doi.org/10.4103/1947-2714.101979 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Andrén-Sandberg, Åke
Molecular Biology of Gallbladder Cancer: Potential Clinical Implications
title Molecular Biology of Gallbladder Cancer: Potential Clinical Implications
title_full Molecular Biology of Gallbladder Cancer: Potential Clinical Implications
title_fullStr Molecular Biology of Gallbladder Cancer: Potential Clinical Implications
title_full_unstemmed Molecular Biology of Gallbladder Cancer: Potential Clinical Implications
title_short Molecular Biology of Gallbladder Cancer: Potential Clinical Implications
title_sort molecular biology of gallbladder cancer: potential clinical implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482772/
https://www.ncbi.nlm.nih.gov/pubmed/23112962
http://dx.doi.org/10.4103/1947-2714.101979
work_keys_str_mv AT andrensandbergake molecularbiologyofgallbladdercancerpotentialclinicalimplications