Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing

[Image: see text] Genomic applications of DNA-binding molecules require an unbiased knowledge of their high affinity sites. We report the high-throughput analysis of pyrrole-imidazole polyamide DNA-binding specificity in a 10(12)-member DNA sequence library using affinity purification coupled with m...

Descripción completa

Detalles Bibliográficos
Autores principales: Meier, Jordan L., Yu, Abigail S., Korf, Ian, Segal, David J., Dervan, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483022/
https://www.ncbi.nlm.nih.gov/pubmed/23013524
http://dx.doi.org/10.1021/ja308888c

Ejemplares similares

Ejemplares similares