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TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

The metalloprotease ADAM10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Notch. Here, we show that the human tetraspanins of the evolutionary conserved TspanC8 subfamily (Tspan5, Tspan10, Tspan14, Tspan15, Tspan17, and Tspan33) directly interact with A...

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Detalles Bibliográficos
Autores principales:	Dornier, Emmanuel, Coumailleau, Franck, Ottavi, Jean-François, Moretti, Julien, Boucheix, Claude, Mauduit, Philippe, Schweisguth, François, Rubinstein, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483123/ https://www.ncbi.nlm.nih.gov/pubmed/23091066 http://dx.doi.org/10.1083/jcb.201201133

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