N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

Metastasizing tumor cells use matrix metalloproteases, such as the transmembrane collagenase MT1-MMP, together with actin-based protrusions, to break through extracellular matrix barriers and migrate in dense matrix. Here we show that the actin nucleation–promoting protein N-WASP (Neural Wiskott-Ald...

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Detalles Bibliográficos
Autores principales: Yu, Xinzi, Zech, Tobias, McDonald, Laura, Gonzalez, Esther Garcia, Li, Ang, Macpherson, Iain, Schwarz, Juliane P., Spence, Heather, Futó, Kinga, Timpson, Paul, Nixon, Colin, Ma, Yafeng, Anton, Ines M., Visegrády, Balázs, Insall, Robert H., Oien, Karin, Blyth, Karen, Norman, Jim C., Machesky, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483131/
https://www.ncbi.nlm.nih.gov/pubmed/23091069
http://dx.doi.org/10.1083/jcb.201203025

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