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Potentiation of Thrombin Generation in Hemophilia A Plasma by Coagulation Factor VIII and Characterization of Antibody-Specific Inhibition

Development of inhibitory antibodies to coagulation factor VIII (fVIII) is the primary obstacle to the treatment of hemophilia A in the developed world. This adverse reaction occurs in 20–30% of persons with severe hemophilia A treated with fVIII-replacement products and is characterized by the deve...

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Detalles Bibliográficos
Autores principales:	Doshi, Bhavya S., Gangadharan, Bagirath, Doering, Christopher B., Meeks, Shannon L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483154/ https://www.ncbi.nlm.nih.gov/pubmed/23144741 http://dx.doi.org/10.1371/journal.pone.0048172

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