Chromatin roadblocks to reprogramming 50 years on

A half century after John Gurdon demonstrated nuclear reprogramming, for which he was awarded the 2012 Nobel Prize in Physiology or Medicine, his group provides insights into the molecular mechanisms whereby chromatin remodeling is required for nuclear reprogramming. Among the issues addressed in Gu...

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Detalles Bibliográficos
Autores principales: Skene, Peter J, Henikoff, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483161/
https://www.ncbi.nlm.nih.gov/pubmed/23107587
http://dx.doi.org/10.1186/1741-7007-10-83
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author Skene, Peter J
Henikoff, Steven
author_facet Skene, Peter J
Henikoff, Steven
author_sort Skene, Peter J
collection PubMed
description A half century after John Gurdon demonstrated nuclear reprogramming, for which he was awarded the 2012 Nobel Prize in Physiology or Medicine, his group provides insights into the molecular mechanisms whereby chromatin remodeling is required for nuclear reprogramming. Among the issues addressed in Gurdon's latest work are the chromatin impediments to artificially induced reprogramming, discovered by Shinya Yamanaka, who shared the award with Gurdon. See research article: http://www.epigeneticsandchromatin.com/content/5/1/17
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spelling pubmed-34831612012-10-30 Chromatin roadblocks to reprogramming 50 years on Skene, Peter J Henikoff, Steven BMC Biol Commentary A half century after John Gurdon demonstrated nuclear reprogramming, for which he was awarded the 2012 Nobel Prize in Physiology or Medicine, his group provides insights into the molecular mechanisms whereby chromatin remodeling is required for nuclear reprogramming. Among the issues addressed in Gurdon's latest work are the chromatin impediments to artificially induced reprogramming, discovered by Shinya Yamanaka, who shared the award with Gurdon. See research article: http://www.epigeneticsandchromatin.com/content/5/1/17 BioMed Central 2012-10-29 /pmc/articles/PMC3483161/ /pubmed/23107587 http://dx.doi.org/10.1186/1741-7007-10-83 Text en Copyright ©2012 Skene and Henikoff; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Skene, Peter J
Henikoff, Steven
Chromatin roadblocks to reprogramming 50 years on
title Chromatin roadblocks to reprogramming 50 years on
title_full Chromatin roadblocks to reprogramming 50 years on
title_fullStr Chromatin roadblocks to reprogramming 50 years on
title_full_unstemmed Chromatin roadblocks to reprogramming 50 years on
title_short Chromatin roadblocks to reprogramming 50 years on
title_sort chromatin roadblocks to reprogramming 50 years on
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483161/
https://www.ncbi.nlm.nih.gov/pubmed/23107587
http://dx.doi.org/10.1186/1741-7007-10-83
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