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Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease

BACKGROUND: Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disease (AD). Processing involves monomeric and dimeric forms of APP that traffic th...

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Detalles Bibliográficos
Autores principales:	Lao, Angelyn, Schmidt, Vanessa, Schmitz, Yvonne, Willnow, Thomas E, Wolkenhauer, Olaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483162/ https://www.ncbi.nlm.nih.gov/pubmed/22727043 http://dx.doi.org/10.1186/1752-0509-6-74

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