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Quantitative Comparison of the Efficacy of Various Compounds in Lowering Intracellular Cholesterol Levels in Niemann-Pick Type C Fibroblasts

Niemann-Pick Type C disease (NPC) is a lethal, autosomal recessive disorder caused by mutations in the NPC1 and NPC2 cholesterol transport proteins. NPC’s hallmark symptoms include an accumulation of unesterified cholesterol and other lipids in the late endosomal and lysosomal cellular compartments,...

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Detalles Bibliográficos
Autores principales:	Wehrmann, Zachary T., Hulett, Tyler W., Huegel, Kara L., Vaughan, Kevin T., Wiest, Olaf, Helquist, Paul, Goodson, Holly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483179/ https://www.ncbi.nlm.nih.gov/pubmed/23144769 http://dx.doi.org/10.1371/journal.pone.0048561

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