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Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study
BACKGROUND: Malaria in pregnancy has a negative impact on foetal growth, but it is not known whether this also affects the foetal nervous system. The aim of this study was to examine the effects of malaria on foetal cortex development by three-dimensional ultrasound. METHODS: Brain images were acqui...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483189/ https://www.ncbi.nlm.nih.gov/pubmed/22747687 http://dx.doi.org/10.1186/1475-2875-11-222 |
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author | Rijken, Marcus J de Wit, Merel Charlotte Mulder, Eduard JH Kiricharoen, Suporn Karunkonkowit, Noaeni Paw, Tamalar Visser, Gerard HA McGready, Rose Nosten, François H Pistorius, Lourens R |
author_facet | Rijken, Marcus J de Wit, Merel Charlotte Mulder, Eduard JH Kiricharoen, Suporn Karunkonkowit, Noaeni Paw, Tamalar Visser, Gerard HA McGready, Rose Nosten, François H Pistorius, Lourens R |
author_sort | Rijken, Marcus J |
collection | PubMed |
description | BACKGROUND: Malaria in pregnancy has a negative impact on foetal growth, but it is not known whether this also affects the foetal nervous system. The aim of this study was to examine the effects of malaria on foetal cortex development by three-dimensional ultrasound. METHODS: Brain images were acquired using a portable ultrasound machine and a 3D ultrasound transducer. All recordings were analysed, blinded to clinical data, using the 4D view software package. The foetal supra-tentorial brain volume was determined and cortical development was qualitatively followed by scoring the appearance and development of six sulci. Multilevel analysis was used to study brain volume and cortical development in individual foetuses. RESULTS: Cortical grading was possible in 161 out of 223 (72%) serial foetal brain images in pregnant women living in a malaria endemic area. There was no difference between foetal cortical development or brain volumes at any time in pregnancy between women with immediately treated malaria infections and non-infected pregnancies. CONCLUSION: The percentage of images that could be graded was similar to other neuro-sonographic studies. Maternal malaria does not have a gross effect on foetal brain development, at least in this population, which had access to early detection and effective treatment of malaria. |
format | Online Article Text |
id | pubmed-3483189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34831892012-10-30 Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study Rijken, Marcus J de Wit, Merel Charlotte Mulder, Eduard JH Kiricharoen, Suporn Karunkonkowit, Noaeni Paw, Tamalar Visser, Gerard HA McGready, Rose Nosten, François H Pistorius, Lourens R Malar J Research BACKGROUND: Malaria in pregnancy has a negative impact on foetal growth, but it is not known whether this also affects the foetal nervous system. The aim of this study was to examine the effects of malaria on foetal cortex development by three-dimensional ultrasound. METHODS: Brain images were acquired using a portable ultrasound machine and a 3D ultrasound transducer. All recordings were analysed, blinded to clinical data, using the 4D view software package. The foetal supra-tentorial brain volume was determined and cortical development was qualitatively followed by scoring the appearance and development of six sulci. Multilevel analysis was used to study brain volume and cortical development in individual foetuses. RESULTS: Cortical grading was possible in 161 out of 223 (72%) serial foetal brain images in pregnant women living in a malaria endemic area. There was no difference between foetal cortical development or brain volumes at any time in pregnancy between women with immediately treated malaria infections and non-infected pregnancies. CONCLUSION: The percentage of images that could be graded was similar to other neuro-sonographic studies. Maternal malaria does not have a gross effect on foetal brain development, at least in this population, which had access to early detection and effective treatment of malaria. BioMed Central 2012-07-02 /pmc/articles/PMC3483189/ /pubmed/22747687 http://dx.doi.org/10.1186/1475-2875-11-222 Text en Copyright ©2012 Rijken et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Rijken, Marcus J de Wit, Merel Charlotte Mulder, Eduard JH Kiricharoen, Suporn Karunkonkowit, Noaeni Paw, Tamalar Visser, Gerard HA McGready, Rose Nosten, François H Pistorius, Lourens R Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study |
title | Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study |
title_full | Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study |
title_fullStr | Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study |
title_full_unstemmed | Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study |
title_short | Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study |
title_sort | effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483189/ https://www.ncbi.nlm.nih.gov/pubmed/22747687 http://dx.doi.org/10.1186/1475-2875-11-222 |
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