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Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene

BACKGROUND: P-glycoprotein is a blood–brain barrier efflux transporter involved in the clearance of amyloid-beta from the brain and, as such, might be involved in the pathogenesis of Alzheimer's disease. P-glycoprotein is encoded by the highly polymorphic ABCB1 gene. Single-nucleotide polymorph...

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Detalles Bibliográficos
Autores principales:	van Assema, Daniëlle ME, Lubberink, Mark, Rizzu, Patrizia, van Swieten, John C, Schuit, Robert C, Eriksson, Jonas, Scheltens, Philip, Koepp, Matthias, Lammertsma, Adriaan A, van Berckel, Bart NM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483228/ https://www.ncbi.nlm.nih.gov/pubmed/23067778 http://dx.doi.org/10.1186/2191-219X-2-57

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