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Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis

OBJECTIVE: Myocarditis is an inflammation of the myocardium. The condition is commonly associated with rapid disease progression and often results in profound shock. Impaired renal function is the result of impairment in end-organ perfusion and is highly prevalent among critically ill patients. The...

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Autores principales: Yang, Ya-Wen, Wu, Che-Hsiung, Ko, Wen-Je, Wu, Vin-Cent, Chen, Jin-Shing, Chou, Nai-Kuan, Lai, Hong-Shiee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483268/
https://www.ncbi.nlm.nih.gov/pubmed/23144725
http://dx.doi.org/10.1371/journal.pone.0048055
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author Yang, Ya-Wen
Wu, Che-Hsiung
Ko, Wen-Je
Wu, Vin-Cent
Chen, Jin-Shing
Chou, Nai-Kuan
Lai, Hong-Shiee
author_facet Yang, Ya-Wen
Wu, Che-Hsiung
Ko, Wen-Je
Wu, Vin-Cent
Chen, Jin-Shing
Chou, Nai-Kuan
Lai, Hong-Shiee
author_sort Yang, Ya-Wen
collection PubMed
description OBJECTIVE: Myocarditis is an inflammation of the myocardium. The condition is commonly associated with rapid disease progression and often results in profound shock. Impaired renal function is the result of impairment in end-organ perfusion and is highly prevalent among critically ill patients. The aim of this study was to evaluate the incidence of acute kidney injury (AKI) and identify the relationship between AKI and the prognosis of patients with acute myocarditis. DESIGN, MEASUREMENTS AND MAIN RESULTS: This retrospective study reviewed the medical records of 101 patients suffering from acute myocarditis between 1996 and 2011. Sixty of these patients (59%) developed AKI within 48 hours of being hospitalized. AKI defined as AKIN stage 3 (p = 0.007) and SOFA score (p = 0.03) were identified as predictors of in-hospital mortality in multivariate analysis. The conditional effect plot of the estimated risk against SOFA score upon admission categorized according to the AKIN stages showed that the risk of in-hospital mortality was highest among patients in AKIN stage 3 with a high SOFA score. CONCLUSIONS: Among patients with acute myocarditis, AKI defined as AKIN stage 3 and elevated SOFA score were associated with unfavorable outcomes. AKIN classification is a simple, reproducible, and easily applied evaluation tool capable of providing objective information related to the clinical prognosis of patients with acute myocarditis.
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spelling pubmed-34832682012-11-09 Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis Yang, Ya-Wen Wu, Che-Hsiung Ko, Wen-Je Wu, Vin-Cent Chen, Jin-Shing Chou, Nai-Kuan Lai, Hong-Shiee PLoS One Research Article OBJECTIVE: Myocarditis is an inflammation of the myocardium. The condition is commonly associated with rapid disease progression and often results in profound shock. Impaired renal function is the result of impairment in end-organ perfusion and is highly prevalent among critically ill patients. The aim of this study was to evaluate the incidence of acute kidney injury (AKI) and identify the relationship between AKI and the prognosis of patients with acute myocarditis. DESIGN, MEASUREMENTS AND MAIN RESULTS: This retrospective study reviewed the medical records of 101 patients suffering from acute myocarditis between 1996 and 2011. Sixty of these patients (59%) developed AKI within 48 hours of being hospitalized. AKI defined as AKIN stage 3 (p = 0.007) and SOFA score (p = 0.03) were identified as predictors of in-hospital mortality in multivariate analysis. The conditional effect plot of the estimated risk against SOFA score upon admission categorized according to the AKIN stages showed that the risk of in-hospital mortality was highest among patients in AKIN stage 3 with a high SOFA score. CONCLUSIONS: Among patients with acute myocarditis, AKI defined as AKIN stage 3 and elevated SOFA score were associated with unfavorable outcomes. AKIN classification is a simple, reproducible, and easily applied evaluation tool capable of providing objective information related to the clinical prognosis of patients with acute myocarditis. Public Library of Science 2012-10-29 /pmc/articles/PMC3483268/ /pubmed/23144725 http://dx.doi.org/10.1371/journal.pone.0048055 Text en © 2012 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Ya-Wen
Wu, Che-Hsiung
Ko, Wen-Je
Wu, Vin-Cent
Chen, Jin-Shing
Chou, Nai-Kuan
Lai, Hong-Shiee
Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis
title Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis
title_full Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis
title_fullStr Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis
title_full_unstemmed Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis
title_short Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis
title_sort prevalence of acute kidney injury and prognostic significance in patients with acute myocarditis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483268/
https://www.ncbi.nlm.nih.gov/pubmed/23144725
http://dx.doi.org/10.1371/journal.pone.0048055
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