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UPR-Induced Resistance to Etoposide Is Downstream of PERK and Independent of Changes in Topoisomerase IIα Levels

BACKGROUND: The unfolded protein response (UPR) is regulated by three ER-localized, transmembrane signal transducers that control distinct aspects of the UPR. We previously reported that both increased resistance to etoposide and a reduction in Topoisomerase IIα protein levels were a direct response...

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Detalles Bibliográficos
Autores principales:	Mann, Melissa J., Pereira, Ethel R., Liao, Nan, Hendershot, Linda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483293/ https://www.ncbi.nlm.nih.gov/pubmed/23144714 http://dx.doi.org/10.1371/journal.pone.0047931

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