Evidence for Abasic Site Sugar Phosphate-Mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces cerevisiae

To better understand alkylating agent-induced cytotoxicity and the base lesion DNA repair process in Saccharomyces cerevisiae, we replaced the RAD27(FEN1) open reading frame (ORF) with the ORF of the bifunctional human repair enzyme DNA polymerase (Pol) β. The aim was to probe the effect of removal...

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Detalles Bibliográficos
Autores principales: Heacock, Michelle, Poltoratsky, Vladimir, Prasad, Rajendra, Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483300/
https://www.ncbi.nlm.nih.gov/pubmed/23144716
http://dx.doi.org/10.1371/journal.pone.0047945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483300/
https://www.ncbi.nlm.nih.gov/pubmed/23144716
http://dx.doi.org/10.1371/journal.pone.0047945

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