Cargando…
Evidence for Abasic Site Sugar Phosphate-Mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces cerevisiae
To better understand alkylating agent-induced cytotoxicity and the base lesion DNA repair process in Saccharomyces cerevisiae, we replaced the RAD27(FEN1) open reading frame (ORF) with the ORF of the bifunctional human repair enzyme DNA polymerase (Pol) β. The aim was to probe the effect of removal...
Autores principales: | Heacock, Michelle, Poltoratsky, Vladimir, Prasad, Rajendra, Wilson, Samuel H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483300/ https://www.ncbi.nlm.nih.gov/pubmed/23144716 http://dx.doi.org/10.1371/journal.pone.0047945 |
Ejemplares similares
-
Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae
por: Kow, Yoke W., et al.
Publicado: (2005) -
RNA abasic sites in yeast and human cells
por: Liu, Yaojuan, et al.
Publicado: (2020) -
Rev1 is a base excision repair enzyme with 5′-deoxyribose phosphate lyase activity
por: Prasad, Rajendra, et al.
Publicado: (2016) -
Nucleosomal embedding reshapes the dynamics of abasic sites
por: Bignon, Emmanuelle, et al.
Publicado: (2020) -
Dual chemical labeling enables nucleotide-resolution mapping of DNA abasic sites and common alkylation damage in human mitochondrial DNA
por: Liu, Chaoxing, et al.
Publicado: (2023)