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Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

Intratumoral hypoxia is a major obstacle in the development of effective cancer chemotherapy, decreasing the efficacy of anti-neoplastic drugs in several solid tumours. The hypoxic environment, through its master regulator hypoxia inducible factor-1 (HIF-1), is able to maintain an anti-apoptotic pot...

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Detalles Bibliográficos
Autores principales:	Calvani, Maura, Comito, Giuseppina, Giannoni, Elisa, Chiarugi, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483303/ https://www.ncbi.nlm.nih.gov/pubmed/23144690 http://dx.doi.org/10.1371/journal.pone.0038388

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