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Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess
Metronidazole-induced encephalopathy is a very rare complication of the long standing use of metronidazole. The encephalopathy is bilateral and symmetric in nature. We report on the magnetic resonance imaging (MRI) and clinical course of metronidazole-induced encephalopathy in a 60-year-old female w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Neurosurgical Society
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483336/ https://www.ncbi.nlm.nih.gov/pubmed/23115678 http://dx.doi.org/10.3340/jkns.2012.52.3.273 |
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author | Jang, Han Jin Sim, Sook Young Lee, Jong Yun Bang, Ji Hwan |
author_facet | Jang, Han Jin Sim, Sook Young Lee, Jong Yun Bang, Ji Hwan |
author_sort | Jang, Han Jin |
collection | PubMed |
description | Metronidazole-induced encephalopathy is a very rare complication of the long standing use of metronidazole. The encephalopathy is bilateral and symmetric in nature. We report on the magnetic resonance imaging (MRI) and clinical course of metronidazole-induced encephalopathy in a 60-year-old female with a persistent anaerobic brain abscess after draining of the abscess. After 3 months of metronidazole administration, the patient complained of dysarthria, tingling sense of all extremities, and left hemiparesis. MRI revealed symmetric hyperintensity lesions in medulla, pons, dentate nuclei of cerebellum, and splenium of corpus callosum, all of which represent typical findings of metronidazole-induced encephalopathy. In addition, asymmetric lesions in midbrain, thalamus, putamen and cerebral subcortical white matter were noted. The patient recovered after discontinuation of metronidazole and the remaining abscess was successfully treated with meropenem and levofloxacine. |
format | Online Article Text |
id | pubmed-3483336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-34833362012-10-31 Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess Jang, Han Jin Sim, Sook Young Lee, Jong Yun Bang, Ji Hwan J Korean Neurosurg Soc Case Report Metronidazole-induced encephalopathy is a very rare complication of the long standing use of metronidazole. The encephalopathy is bilateral and symmetric in nature. We report on the magnetic resonance imaging (MRI) and clinical course of metronidazole-induced encephalopathy in a 60-year-old female with a persistent anaerobic brain abscess after draining of the abscess. After 3 months of metronidazole administration, the patient complained of dysarthria, tingling sense of all extremities, and left hemiparesis. MRI revealed symmetric hyperintensity lesions in medulla, pons, dentate nuclei of cerebellum, and splenium of corpus callosum, all of which represent typical findings of metronidazole-induced encephalopathy. In addition, asymmetric lesions in midbrain, thalamus, putamen and cerebral subcortical white matter were noted. The patient recovered after discontinuation of metronidazole and the remaining abscess was successfully treated with meropenem and levofloxacine. The Korean Neurosurgical Society 2012-09 2012-09-30 /pmc/articles/PMC3483336/ /pubmed/23115678 http://dx.doi.org/10.3340/jkns.2012.52.3.273 Text en Copyright © 2012 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Jang, Han Jin Sim, Sook Young Lee, Jong Yun Bang, Ji Hwan Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess |
title | Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess |
title_full | Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess |
title_fullStr | Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess |
title_full_unstemmed | Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess |
title_short | Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess |
title_sort | atypical metronidazole-induced encephalopathy in anaerobic brain abscess |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483336/ https://www.ncbi.nlm.nih.gov/pubmed/23115678 http://dx.doi.org/10.3340/jkns.2012.52.3.273 |
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