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Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess

Metronidazole-induced encephalopathy is a very rare complication of the long standing use of metronidazole. The encephalopathy is bilateral and symmetric in nature. We report on the magnetic resonance imaging (MRI) and clinical course of metronidazole-induced encephalopathy in a 60-year-old female w...

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Detalles Bibliográficos
Autores principales: Jang, Han Jin, Sim, Sook Young, Lee, Jong Yun, Bang, Ji Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Neurosurgical Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483336/
https://www.ncbi.nlm.nih.gov/pubmed/23115678
http://dx.doi.org/10.3340/jkns.2012.52.3.273
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author Jang, Han Jin
Sim, Sook Young
Lee, Jong Yun
Bang, Ji Hwan
author_facet Jang, Han Jin
Sim, Sook Young
Lee, Jong Yun
Bang, Ji Hwan
author_sort Jang, Han Jin
collection PubMed
description Metronidazole-induced encephalopathy is a very rare complication of the long standing use of metronidazole. The encephalopathy is bilateral and symmetric in nature. We report on the magnetic resonance imaging (MRI) and clinical course of metronidazole-induced encephalopathy in a 60-year-old female with a persistent anaerobic brain abscess after draining of the abscess. After 3 months of metronidazole administration, the patient complained of dysarthria, tingling sense of all extremities, and left hemiparesis. MRI revealed symmetric hyperintensity lesions in medulla, pons, dentate nuclei of cerebellum, and splenium of corpus callosum, all of which represent typical findings of metronidazole-induced encephalopathy. In addition, asymmetric lesions in midbrain, thalamus, putamen and cerebral subcortical white matter were noted. The patient recovered after discontinuation of metronidazole and the remaining abscess was successfully treated with meropenem and levofloxacine.
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spelling pubmed-34833362012-10-31 Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess Jang, Han Jin Sim, Sook Young Lee, Jong Yun Bang, Ji Hwan J Korean Neurosurg Soc Case Report Metronidazole-induced encephalopathy is a very rare complication of the long standing use of metronidazole. The encephalopathy is bilateral and symmetric in nature. We report on the magnetic resonance imaging (MRI) and clinical course of metronidazole-induced encephalopathy in a 60-year-old female with a persistent anaerobic brain abscess after draining of the abscess. After 3 months of metronidazole administration, the patient complained of dysarthria, tingling sense of all extremities, and left hemiparesis. MRI revealed symmetric hyperintensity lesions in medulla, pons, dentate nuclei of cerebellum, and splenium of corpus callosum, all of which represent typical findings of metronidazole-induced encephalopathy. In addition, asymmetric lesions in midbrain, thalamus, putamen and cerebral subcortical white matter were noted. The patient recovered after discontinuation of metronidazole and the remaining abscess was successfully treated with meropenem and levofloxacine. The Korean Neurosurgical Society 2012-09 2012-09-30 /pmc/articles/PMC3483336/ /pubmed/23115678 http://dx.doi.org/10.3340/jkns.2012.52.3.273 Text en Copyright © 2012 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Jang, Han Jin
Sim, Sook Young
Lee, Jong Yun
Bang, Ji Hwan
Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess
title Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess
title_full Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess
title_fullStr Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess
title_full_unstemmed Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess
title_short Atypical Metronidazole-Induced Encephalopathy in Anaerobic Brain Abscess
title_sort atypical metronidazole-induced encephalopathy in anaerobic brain abscess
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483336/
https://www.ncbi.nlm.nih.gov/pubmed/23115678
http://dx.doi.org/10.3340/jkns.2012.52.3.273
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