Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis

Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by an increased risk of myeloid malignancies. Exome sequencing of 3 elderly females with clonal hematopoiesis demonstrated by X-inactivation analysis identified somatic TET2 mutations. Recurrence testing found...

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Autores principales: Busque, Lambert, Patel, Jay P., Figueroa, Maria, Vasanthakumar, Aparna, Provost, Sylvie, Hamilou, Zineb, Mollica, Luigina, Li, Juan, Viale, Agnes, Heguy, Adriana, Hassimi, Maryam, Socci, Nicholas, Bhatt, Parva K., Gonen, Mithat, Mason, Christopher E., Melnick, Ari, Godley, Lucy A., Brennan, Cameron, Abdel-Wahab, Omar, Levine, Ross L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483435/
https://www.ncbi.nlm.nih.gov/pubmed/23001125
http://dx.doi.org/10.1038/ng.2413
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author Busque, Lambert
Patel, Jay P.
Figueroa, Maria
Vasanthakumar, Aparna
Provost, Sylvie
Hamilou, Zineb
Mollica, Luigina
Li, Juan
Viale, Agnes
Heguy, Adriana
Hassimi, Maryam
Socci, Nicholas
Bhatt, Parva K.
Gonen, Mithat
Mason, Christopher E.
Melnick, Ari
Godley, Lucy A.
Brennan, Cameron
Abdel-Wahab, Omar
Levine, Ross L.
author_facet Busque, Lambert
Patel, Jay P.
Figueroa, Maria
Vasanthakumar, Aparna
Provost, Sylvie
Hamilou, Zineb
Mollica, Luigina
Li, Juan
Viale, Agnes
Heguy, Adriana
Hassimi, Maryam
Socci, Nicholas
Bhatt, Parva K.
Gonen, Mithat
Mason, Christopher E.
Melnick, Ari
Godley, Lucy A.
Brennan, Cameron
Abdel-Wahab, Omar
Levine, Ross L.
author_sort Busque, Lambert
collection PubMed
description Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by an increased risk of myeloid malignancies. Exome sequencing of 3 elderly females with clonal hematopoiesis demonstrated by X-inactivation analysis identified somatic TET2 mutations. Recurrence testing found TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematologic malignancies and were associated with alterations in DNA methylation.
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spelling pubmed-34834352013-05-01 Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis Busque, Lambert Patel, Jay P. Figueroa, Maria Vasanthakumar, Aparna Provost, Sylvie Hamilou, Zineb Mollica, Luigina Li, Juan Viale, Agnes Heguy, Adriana Hassimi, Maryam Socci, Nicholas Bhatt, Parva K. Gonen, Mithat Mason, Christopher E. Melnick, Ari Godley, Lucy A. Brennan, Cameron Abdel-Wahab, Omar Levine, Ross L. Nat Genet Article Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by an increased risk of myeloid malignancies. Exome sequencing of 3 elderly females with clonal hematopoiesis demonstrated by X-inactivation analysis identified somatic TET2 mutations. Recurrence testing found TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematologic malignancies and were associated with alterations in DNA methylation. 2012-09-23 2012-11 /pmc/articles/PMC3483435/ /pubmed/23001125 http://dx.doi.org/10.1038/ng.2413 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Busque, Lambert
Patel, Jay P.
Figueroa, Maria
Vasanthakumar, Aparna
Provost, Sylvie
Hamilou, Zineb
Mollica, Luigina
Li, Juan
Viale, Agnes
Heguy, Adriana
Hassimi, Maryam
Socci, Nicholas
Bhatt, Parva K.
Gonen, Mithat
Mason, Christopher E.
Melnick, Ari
Godley, Lucy A.
Brennan, Cameron
Abdel-Wahab, Omar
Levine, Ross L.
Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis
title Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis
title_full Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis
title_fullStr Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis
title_full_unstemmed Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis
title_short Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis
title_sort recurrent somatic tet2 mutations in normal elderly individuals with clonal hematopoiesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483435/
https://www.ncbi.nlm.nih.gov/pubmed/23001125
http://dx.doi.org/10.1038/ng.2413
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