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OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons

The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types have been hampered by the lack of cell specific tools. Here we report...

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Autores principales: Leão, Richardson N, Mikulovic, Sanja, Leão, Katarina E, Munguba, Hermany, Gezelius, Henrik, Enjin, Anders, Patra, Kalicharan, Eriksson, Anders, Loew, Leslie M., Tort, Adriano BL, Kullander, Klas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483451/
https://www.ncbi.nlm.nih.gov/pubmed/23042082
http://dx.doi.org/10.1038/nn.3235
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author Leão, Richardson N
Mikulovic, Sanja
Leão, Katarina E
Munguba, Hermany
Gezelius, Henrik
Enjin, Anders
Patra, Kalicharan
Eriksson, Anders
Loew, Leslie M.
Tort, Adriano BL
Kullander, Klas
author_facet Leão, Richardson N
Mikulovic, Sanja
Leão, Katarina E
Munguba, Hermany
Gezelius, Henrik
Enjin, Anders
Patra, Kalicharan
Eriksson, Anders
Loew, Leslie M.
Tort, Adriano BL
Kullander, Klas
author_sort Leão, Richardson N
collection PubMed
description The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types have been hampered by the lack of cell specific tools. Here we report a precise molecular marker for a population of hippocampal GABAergic interneurons known as oriens lacunosum-moleculare (OLM) cells. By combining novel transgenic mice and optogenetic tools, we demonstrate that OLM cells have a key role in gating the information flow in CA1, facilitating the transmission of intrahippocampal information (from CA3) while reducing the influence of extrahippocampal inputs (from the entorhinal cortex). We further demonstrate that OLM cells are interconnected by gap junctions, receive direct cholinergic inputs from subcortical afferents, and account for the effect of nicotine on synaptic plasticity of the Schaffer collateral pathway. Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus.
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spelling pubmed-34834512013-05-01 OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons Leão, Richardson N Mikulovic, Sanja Leão, Katarina E Munguba, Hermany Gezelius, Henrik Enjin, Anders Patra, Kalicharan Eriksson, Anders Loew, Leslie M. Tort, Adriano BL Kullander, Klas Nat Neurosci Article The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types have been hampered by the lack of cell specific tools. Here we report a precise molecular marker for a population of hippocampal GABAergic interneurons known as oriens lacunosum-moleculare (OLM) cells. By combining novel transgenic mice and optogenetic tools, we demonstrate that OLM cells have a key role in gating the information flow in CA1, facilitating the transmission of intrahippocampal information (from CA3) while reducing the influence of extrahippocampal inputs (from the entorhinal cortex). We further demonstrate that OLM cells are interconnected by gap junctions, receive direct cholinergic inputs from subcortical afferents, and account for the effect of nicotine on synaptic plasticity of the Schaffer collateral pathway. Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus. 2012-10-07 2012-11 /pmc/articles/PMC3483451/ /pubmed/23042082 http://dx.doi.org/10.1038/nn.3235 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Leão, Richardson N
Mikulovic, Sanja
Leão, Katarina E
Munguba, Hermany
Gezelius, Henrik
Enjin, Anders
Patra, Kalicharan
Eriksson, Anders
Loew, Leslie M.
Tort, Adriano BL
Kullander, Klas
OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
title OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
title_full OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
title_fullStr OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
title_full_unstemmed OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
title_short OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
title_sort olm interneurons differentially modulate ca3 and entorhinal inputs to hippocampal ca1 neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483451/
https://www.ncbi.nlm.nih.gov/pubmed/23042082
http://dx.doi.org/10.1038/nn.3235
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