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Silicon, a Possible Link between Environmental Exposure and Autoimmune Diseases: The Case of Rheumatoid Arthritis
Silicon is one of the most common chemicals on earth. Several compounds such as silica, asbestos, silicone or, nanoparticles are built from tetrahedral units with silicon as the central atom. Despite these, structural similarities, they have rarely been analyzed as a group. These compounds generate...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483651/ https://www.ncbi.nlm.nih.gov/pubmed/23119159 http://dx.doi.org/10.1155/2012/604187 |
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author | Speck-Hernandez, Cesar A. Montoya-Ortiz, Gladis |
author_facet | Speck-Hernandez, Cesar A. Montoya-Ortiz, Gladis |
author_sort | Speck-Hernandez, Cesar A. |
collection | PubMed |
description | Silicon is one of the most common chemicals on earth. Several compounds such as silica, asbestos, silicone or, nanoparticles are built from tetrahedral units with silicon as the central atom. Despite these, structural similarities, they have rarely been analyzed as a group. These compounds generate significant biological alterations that include immune hyperactivation, production of the reactive species of oxygen and tissue injury. These pathological processes may trigger autoimmune responses and lead to the development of rheumatoid arthritis. Populations at risk include those that constantly work in industrial process, mining, and agriculture as well as those that undergo silicone implants. Herein a review on the main features of these compounds and how they may induce autoimmune responses is presented. |
format | Online Article Text |
id | pubmed-3483651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34836512012-11-01 Silicon, a Possible Link between Environmental Exposure and Autoimmune Diseases: The Case of Rheumatoid Arthritis Speck-Hernandez, Cesar A. Montoya-Ortiz, Gladis Arthritis Review Article Silicon is one of the most common chemicals on earth. Several compounds such as silica, asbestos, silicone or, nanoparticles are built from tetrahedral units with silicon as the central atom. Despite these, structural similarities, they have rarely been analyzed as a group. These compounds generate significant biological alterations that include immune hyperactivation, production of the reactive species of oxygen and tissue injury. These pathological processes may trigger autoimmune responses and lead to the development of rheumatoid arthritis. Populations at risk include those that constantly work in industrial process, mining, and agriculture as well as those that undergo silicone implants. Herein a review on the main features of these compounds and how they may induce autoimmune responses is presented. Hindawi Publishing Corporation 2012 2012-10-18 /pmc/articles/PMC3483651/ /pubmed/23119159 http://dx.doi.org/10.1155/2012/604187 Text en Copyright © 2012 C. A. Speck-Hernandez and G. Montoya-Ortiz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Speck-Hernandez, Cesar A. Montoya-Ortiz, Gladis Silicon, a Possible Link between Environmental Exposure and Autoimmune Diseases: The Case of Rheumatoid Arthritis |
title | Silicon, a Possible Link between Environmental Exposure and
Autoimmune Diseases: The Case of Rheumatoid Arthritis |
title_full | Silicon, a Possible Link between Environmental Exposure and
Autoimmune Diseases: The Case of Rheumatoid Arthritis |
title_fullStr | Silicon, a Possible Link between Environmental Exposure and
Autoimmune Diseases: The Case of Rheumatoid Arthritis |
title_full_unstemmed | Silicon, a Possible Link between Environmental Exposure and
Autoimmune Diseases: The Case of Rheumatoid Arthritis |
title_short | Silicon, a Possible Link between Environmental Exposure and
Autoimmune Diseases: The Case of Rheumatoid Arthritis |
title_sort | silicon, a possible link between environmental exposure and
autoimmune diseases: the case of rheumatoid arthritis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483651/ https://www.ncbi.nlm.nih.gov/pubmed/23119159 http://dx.doi.org/10.1155/2012/604187 |
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