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The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report

Metastatic carcinomas involving the lung are a common specimen encountered in surgical pathology. These metastases may have different morphologic, and architectural patterns and may mimic primary pulmonary adenocarcinoma, especially the intra-alveolar (lepidic) pattern of spread which may simulate a...

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Autores principales: Alkhasawneh, Ahmed N., Dong, Hui-Jia, Liu, Chen, Allegra, Carmen, Allan, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483662/
https://www.ncbi.nlm.nih.gov/pubmed/23119210
http://dx.doi.org/10.1155/2012/425967
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author Alkhasawneh, Ahmed N.
Dong, Hui-Jia
Liu, Chen
Allegra, Carmen
Allan, Robert W.
author_facet Alkhasawneh, Ahmed N.
Dong, Hui-Jia
Liu, Chen
Allegra, Carmen
Allan, Robert W.
author_sort Alkhasawneh, Ahmed N.
collection PubMed
description Metastatic carcinomas involving the lung are a common specimen encountered in surgical pathology. These metastases may have different morphologic, and architectural patterns and may mimic primary pulmonary adenocarcinoma, especially the intra-alveolar (lepidic) pattern of spread which may simulate a primary pulmonary bronchioloalveolar carcinoma (adenocarcinoma in situ). We present the case of a metastatic pancreatic adenocarcinoma that morphologically mimicked bronchioloalveolar carcinoma of the lung in that the tumor had an exclusive intra-alveolar pattern of spread and had an immunophenotype that was noninformative as to the site of origin (cytokeratin 7+, cytokeratin 20−, TTF-1−). In this case, we used KRAS gene mutation analysis to support that the lung carcinoma represented a metastatic pancreatic carcinoma as they both possessed identical codon 12 KRAS mutations. We show that this method may be a useful way to prove site of origin of metastatic carcinoma—particularly if standard morphologic or immunohistochemical analysis is not definitive.
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spelling pubmed-34836622012-11-01 The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report Alkhasawneh, Ahmed N. Dong, Hui-Jia Liu, Chen Allegra, Carmen Allan, Robert W. Case Rep Pathol Case Report Metastatic carcinomas involving the lung are a common specimen encountered in surgical pathology. These metastases may have different morphologic, and architectural patterns and may mimic primary pulmonary adenocarcinoma, especially the intra-alveolar (lepidic) pattern of spread which may simulate a primary pulmonary bronchioloalveolar carcinoma (adenocarcinoma in situ). We present the case of a metastatic pancreatic adenocarcinoma that morphologically mimicked bronchioloalveolar carcinoma of the lung in that the tumor had an exclusive intra-alveolar pattern of spread and had an immunophenotype that was noninformative as to the site of origin (cytokeratin 7+, cytokeratin 20−, TTF-1−). In this case, we used KRAS gene mutation analysis to support that the lung carcinoma represented a metastatic pancreatic carcinoma as they both possessed identical codon 12 KRAS mutations. We show that this method may be a useful way to prove site of origin of metastatic carcinoma—particularly if standard morphologic or immunohistochemical analysis is not definitive. Hindawi Publishing Corporation 2012 2012-10-17 /pmc/articles/PMC3483662/ /pubmed/23119210 http://dx.doi.org/10.1155/2012/425967 Text en Copyright © 2012 Ahmed N. Alkhasawneh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alkhasawneh, Ahmed N.
Dong, Hui-Jia
Liu, Chen
Allegra, Carmen
Allan, Robert W.
The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report
title The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report
title_full The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report
title_fullStr The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report
title_full_unstemmed The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report
title_short The Role of KRAS Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report
title_sort role of kras mutational analysis to determine the site of origin of metastatic carcinoma to the lung: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483662/
https://www.ncbi.nlm.nih.gov/pubmed/23119210
http://dx.doi.org/10.1155/2012/425967
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