Cargando…

Tumor-Induced CD8+ T-Cell Dysfunction in Lung Cancer Patients

Lung cancer is the leading cause of cancer deaths worldwide and one of the most common types of cancers. The limited success of chemotherapy and radiotherapy regimes have highlighted the need to develop new therapies like antitumor immunotherapy. CD8+ T-cells represent a major arm of the cell-mediat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prado-Garcia, Heriberto, Romero-Garcia, Susana, Aguilar-Cazares, Dolores, Meneses-Flores, Manuel, Lopez-Gonzalez, Jose Sullivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483679/ https://www.ncbi.nlm.nih.gov/pubmed/23118782 http://dx.doi.org/10.1155/2012/741741

Ejemplares similares

LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(−) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients
por: Islas-Vazquez, Lorenzo, et al.
Publicado: (2015)

IL-6, NLR, and SII Markers and Their Relation with Alterations in CD8+ T-Lymphocyte Subpopulations in Patients Treated for Lung Adenocarcinoma
por: Islas-Vazquez, Lorenzo, et al.
Publicado: (2020)

Role of DNA Methylation in the Resistance to Therapy in Solid Tumors
por: Romero-Garcia, Susana, et al.
Publicado: (2020)

Lactic Acidosis in the Presence of Glucose Diminishes Warburg Effect in Lung Adenocarcinoma Cells
por: Prado-Garcia, Heriberto, et al.
Publicado: (2020)

Old and New Players of Inflammation and Their Relationship With Cancer Development
por: Chavez-Dominguez, Rodolfo, et al.
Publicado: (2021)

The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity
por: Chavez-Dominguez, Rodolfo, et al.
Publicado: (2020)

Lactic Acidosis Promotes Mitochondrial Biogenesis in Lung Adenocarcinoma Cells, Supporting Proliferation Under Normoxia or Survival Under Hypoxia
por: Romero-Garcia, Susana, et al.
Publicado: (2019)

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
por: Romero-Garcia, Susana, et al.
Publicado: (2016)

Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors
por: Hernández de la Cruz, Olga N., et al.
Publicado: (2020)

Editorial: Molecular basis of epigenetic regulation in cancer therapies
por: Carlos-Reyes, Angeles, et al.
Publicado: (2023)

Determining Factors in the Therapeutic Success of Checkpoint Immunotherapies against PD-L1 in Breast Cancer: A Focus on Epithelial-Mesenchymal Transition Activation
por: Segovia-Mendoza, Mariana, et al.
Publicado: (2021)

Editorial: Immuno-Metabolism in Tumor Microenvironment
por: Prado-García, Heriberto, et al.
Publicado: (2017)

Partners in crime: The feedback loop between metabolic reprogramming and immune checkpoints in the tumor microenvironment
por: Benito-Lopez, Jesus J., et al.
Publicado: (2023)

Histone deacetylases modulate resistance to the therapy in lung cancer
por: Contreras-Sanzón, Estefanía, et al.
Publicado: (2022)

The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment
por: Aguilar-Cazares, Dolores, et al.
Publicado: (2022)

Role of Circular RNAs in the Regulation of Immune Cells in Response to Cancer Therapies
por: Carlos-Reyes, Ángeles, et al.
Publicado: (2022)

Isolation of tumor-resident CD8(+) T cells from human lung tumors
por: Corgnac, Stéphanie, et al.
Publicado: (2021)

Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity
por: Waugh, Katherine A., et al.
Publicado: (2015)

Dietary Compounds as Epigenetic Modulating Agents in Cancer
por: Carlos-Reyes, Ángeles, et al.
Publicado: (2019)

Role of HMGB1 in Cisplatin-Persistent Lung Adenocarcinoma Cell Lines
por: Chavez-Dominguez, Rodolfo L., et al.
Publicado: (2021)

Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma
por: Chavez-Dominguez, Rodolfo, et al.
Publicado: (2023)

The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction
por: Pinzon-Charry, Alberto, et al.
Publicado: (2006)

Nonclassical monocytes potentiate anti-tumoral CD8(+) T cell responses in the lungs
por: Padgett, Lindsey E., et al.
Publicado: (2023)

Contribution of Angiogenesis to Inflammation and Cancer
por: Aguilar-Cazares, Dolores, et al.
Publicado: (2019)

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion
por: Hailemichael, Yared, et al.
Publicado: (2013)

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8(+) T cells
por: Manzo, Teresa, et al.
Publicado: (2020)

PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer
por: Shen, Yang, et al.
Publicado: (2020)

Assessing Cd8 T Cell Number and Dysfunction in the Presence of Antigen
por: Welsh, Raymond M.
Publicado: (2001)

Analysis of tumor infiltrating CD4+ and CD8+ CDR3 sequences reveals shared features putatively associated to the anti-tumor immune response
por: Aran, Andrea, et al.
Publicado: (2023)

Single-Cell Analyses Identify Dysfunctional CD16(+) CD8 T Cells in Smokers
por: Martos, Suzanne N., et al.
Publicado: (2020)

Protocol for the isolation of CD8+ tumor-infiltrating lymphocytes from human tumors and their characterization by single-cell immune profiling and multiome
por: Anadon, Carmen M., et al.
Publicado: (2022)

Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010
por: Vázquez, Alberto Caballero, et al.
Publicado: (2018)

The Roles of CD8(+) and CD4(+) Cells in Tumor Rejection
por: Udono, Heiichiro, et al.
Publicado: (1989)

PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8(+) T lymphocytes
por: Ogando, Jesús, et al.
Publicado: (2019)

Transforming dysfunctional CD8(+) T cells into natural controller–like CD8(+) T cells: can TCF-1 be the magic wand?
por: Takata, Hiroshi, et al.
Publicado: (2022)

Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells
por: Noyes, David, et al.
Publicado: (2022)

Palmitoylated antigens for the induction of anti-tumor CD8(+) T cells and enhanced tumor recognition
por: Stolk, Dorian A., et al.
Publicado: (2021)

CD8(+) T Cell-Mediated Neuronal Dysfunction and Degeneration in Limbic Encephalitis
por: Ehling, Petra, et al.
Publicado: (2015)

Cellular and Molecular Mechanisms of CD8(+) T Cell Differentiation, Dysfunction and Exhaustion
por: Verdon, Daniel J., et al.
Publicado: (2020)

Impact of CD68/(CD3+CD20) Ratio at the Invasive Front of Primary Tumors on Distant Metastasis Development in Breast Cancer
por: Eiró, Noemí, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1k16g5hgtjknbvkti60i6igb0b