Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies

Vasoactive intestinal peptide (VIP) plays diverse and important role in human physiology and physiopathology and their receptors constitute potential targets for the treatment of several diseases such as neurodegenerative disorder, asthma, diabetes, and inflammatory diseases. This article reviews th...

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Detalles Bibliográficos
Autor principal: Langer, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483716/
https://www.ncbi.nlm.nih.gov/pubmed/23115557
http://dx.doi.org/10.3389/fendo.2012.00129
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author Langer, Ingrid
author_facet Langer, Ingrid
author_sort Langer, Ingrid
collection PubMed
description Vasoactive intestinal peptide (VIP) plays diverse and important role in human physiology and physiopathology and their receptors constitute potential targets for the treatment of several diseases such as neurodegenerative disorder, asthma, diabetes, and inflammatory diseases. This article reviews the current knowledge regarding the two VIP receptors, VPAC(1) and VPAC(2), with respect to mechanisms involved in receptor activation, G protein coupling, signaling, regulation, and oligomerization.
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spelling pubmed-34837162012-10-31 Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies Langer, Ingrid Front Endocrinol (Lausanne) Endocrinology Vasoactive intestinal peptide (VIP) plays diverse and important role in human physiology and physiopathology and their receptors constitute potential targets for the treatment of several diseases such as neurodegenerative disorder, asthma, diabetes, and inflammatory diseases. This article reviews the current knowledge regarding the two VIP receptors, VPAC(1) and VPAC(2), with respect to mechanisms involved in receptor activation, G protein coupling, signaling, regulation, and oligomerization. Frontiers Media S.A. 2012-10-30 /pmc/articles/PMC3483716/ /pubmed/23115557 http://dx.doi.org/10.3389/fendo.2012.00129 Text en Copyright © Langer. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Endocrinology
Langer, Ingrid
Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies
title Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies
title_full Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies
title_fullStr Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies
title_full_unstemmed Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies
title_short Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies
title_sort mechanisms involved in vpac receptors activation and regulation: lessons from pharmacological and mutagenesis studies
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483716/
https://www.ncbi.nlm.nih.gov/pubmed/23115557
http://dx.doi.org/10.3389/fendo.2012.00129
work_keys_str_mv AT langeringrid mechanismsinvolvedinvpacreceptorsactivationandregulationlessonsfrompharmacologicalandmutagenesisstudies

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