5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis

The steroid androst-5-ene-3ß,17ß-diol (5-androstenediol, 5-AED) elevates circulating granulocytes and platelets in animals and humans, and enhances survival during the acute radiation syndrome (ARS) in mice and non-human primates. 5-AED promotes survival of irradiated human hematopoietic progenitors...

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Detalles Bibliográficos
Autores principales: Grace, Marcy B., Singh, Vijay K., Rhee, Juong G., Jackson, William E., Kao, Tzu-Cheg, Whitnall, Mark H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483857/
https://www.ncbi.nlm.nih.gov/pubmed/22843381
http://dx.doi.org/10.1093/jrr/rrs060

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