Cargando…

Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGFβ3

BACKGROUND: Valvulogenesis and septation in the developing heart depend on the formation and remodeling of endocardial cushions in the atrioventricular canal (AVC) and outflow tract (OFT). These cushions are invaded by a subpopulation of endocardial cells that undergo an epithelial-mesenchymal trans...

Descripción completa

Detalles Bibliográficos
Autores principales:	LeMasters, Kathryn E, Blech-Hermoni, Yotam, Stillwagon, Samantha J, Vajda, Natalie A, Ladd, Andrea N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484067/ https://www.ncbi.nlm.nih.gov/pubmed/22866814 http://dx.doi.org/10.1186/1471-213X-12-22

Ejemplares similares

Muscleblind-like 1 is required for normal heart valve development in vivo
por: Coram, Ryan J., et al.
Publicado: (2015)

Identification of transcripts regulated by CUG-BP, Elav-like family member 1 (CELF1) in primary embryonic cardiomyocytes by RNA-seq
por: Blech-Hermoni, Yotam, et al.
Publicado: (2015)

Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle
por: Blech-Hermoni, Yotam, et al.
Publicado: (2016)

Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish
por: Bartman, Thomas, et al.
Publicado: (2004)

Complete endocardial cushion defects in pregnancy: a case report
por: Chen, Xiangjuan, et al.
Publicado: (2014)

Heterotaxy polysplenia syndrome in an adult female with complete endocardial cushion defect
por: Esmat, Habib Ahmad, et al.
Publicado: (2021)

β-Catenin regulates endocardial cushion growth by suppressing p21
por: Liu, Huahua, et al.
Publicado: (2023)

PITX2 Loss-of-Function Mutation Contributes to Congenital Endocardial Cushion Defect and Axenfeld-Rieger Syndrome
por: Zhao, Cui-Mei, et al.
Publicado: (2015)

Ectopia cordis with endocardial cushion defect: Prenatal ultrasonographic diagnosis with autopsy correlation
por: Balakumar, K, et al.
Publicado: (2010)

ERp44 is required for endocardial cushion development by regulating VEGFA secretion in myocardium
por: Bi, Youkun, et al.
Publicado: (2022)

Extracellular Fibrillar Structure of Latent TGFβ Binding Protein-1: Role in TGFβ-dependent Endothelial-Mesenchymal Transformation during Endocardial Cushion Tissue Formation in Mouse Embryonic Heart
por: Nakajima, Yuji, et al.
Publicado: (1997)

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation
por: Singh, Reena, et al.
Publicado: (2011)

Repair of Double Orifice Left AV Valve (DOLAVV) with Endocardial Cushion Defect in Adult
por: Pillai, Vivek Velayudhan, et al.
Publicado: (2017)

Compound loss of muscleblind-like function in myotonic dystrophy
por: Lee, Kuang-Yung, et al.
Publicado: (2013)

Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades
por: Nath, Anjali K., et al.
Publicado: (2008)

Thrombus Formation on the Tricuspid Valve After De Vega’s Annuloplasty and Repair of Endocardial Cushion Defect
por: Efe, Süleyman Çağan, et al.
Publicado: (2014)

Association of Alcohol Use Diagnostic Codes in Pregnancy and Offspring Conotruncal and Endocardial Cushion Heart Defects
por: Harvey, Drayton C., et al.
Publicado: (2022)

Elevated glucose inhibits VEGF-A–mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2
por: Enciso, Josephine M., et al.
Publicado: (2003)

Pdgfrb is a direct regulatory target of TGFβ signaling in atrioventricular cushion mesenchymal cells
por: Peng, Yin, et al.
Publicado: (2017)

Conditional Ablation of Ezh2 in Murine Hearts Reveals Its Essential Roles in Endocardial Cushion Formation, Cardiomyocyte Proliferation and Survival
por: Chen, Li, et al.
Publicado: (2012)

Zebrafish Crip2 Plays a Critical Role in Atrioventricular Valve Development by Downregulating the Expression of ECM Genes in the Endocardial Cushion
por: Kim, Jun-Dae, et al.
Publicado: (2014)

Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells
por: Lee, Mary P, et al.
Publicado: (2014)

Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation
por: Choi, Jongkyu, et al.
Publicado: (2015)

Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice
por: Dasgupta, Twishasri, et al.
Publicado: (2013)

Akt promotes Endocardial-Mesenchyme Transition
por: Meadows, Kafi N, et al.
Publicado: (2009)

Deterministic splicing of Dscam2 is regulated by Muscleblind
por: Li, Joshua Shing Shun, et al.
Publicado: (2019)

Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms
por: Dixon, Donald M., et al.
Publicado: (2015)

Partial endocardial cushion defect combined with persistent left superior vena cava to left atrial roof & cor triatriatum in an adult patient
por: Baek, WK, et al.
Publicado: (2013)

Drosophila Muscleblind Is Involved in troponin T Alternative Splicing and Apoptosis
por: Vicente-Crespo, Marta, et al.
Publicado: (2008)

Alternative splicing of the neurofibromatosis type 1 pre-mRNA is regulated by the muscleblind-like proteins and the CUG-BP and ELAV-like factors
por: Fleming, Victoria A, et al.
Publicado: (2012)

Cushioning Performance of the Biomimetic Cobweb Cushioning Silicone Pad
por: Liao, Changyu, et al.
Publicado: (2023)

Myocardial TGFβ2 Is Required for Atrioventricular Cushion Remodeling and Myocardial Development
por: Bhattacharya, Aniket, et al.
Publicado: (2021)

Gene Expression Analyses during Spontaneous Reversal of Cardiomyopathy in Mice with Repressed Nuclear CUG-BP, Elav-Like Family (CELF) Activity in Heart Muscle
por: Dasgupta, Twishasri, et al.
Publicado: (2015)

Conservation of context-dependent splicing activity in distant Muscleblind homologs
por: Oddo, Julia C., et al.
Publicado: (2016)

Muscleblind-like 2 controls the hypoxia response of cancer cells
por: Fischer, Sandra, et al.
Publicado: (2020)

BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions
por: Dyer, Laura, et al.
Publicado: (2015)

NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development
por: Moazzen, Hoda, et al.
Publicado: (2020)

Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy
por: Machuca-Tzili, Laura E., et al.
Publicado: (2011)

TGF-β1 autocrine signalling and enamel matrix components
por: Kobayashi-Kinoshita, Saeko, et al.
Publicado: (2016)

Correction: BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions
por: Dyer, Laura, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6aquvb7f2kcumajplslo0bq6dq