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BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation

We previously reported the development of a lethal myeloid sarcoma in a non-human primate model utilizing retroviral vectors to genetically modify hematopoietic stem and progenitor cells. This leukemia was characterized by insertion of the vector provirus into the BCL2A1 gene, with resultant BCL2A1...

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Detalles Bibliográficos
Autores principales:	Métais, Jean-Yves, Winkler, Thomas, Geyer, Julia T., Calado, Rodrigo T., Aplan, Peter D., Eckhaus, Michael A., Dunbar, Cynthia E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484072/ https://www.ncbi.nlm.nih.gov/pubmed/23118966 http://dx.doi.org/10.1371/journal.pone.0048267

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