Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

BACKGROUND: Cell-to-cell variability in protein expression can be large, and its propagation through signaling networks affects biological outcomes. Here, we apply deterministic and probabilistic models and biochemical measurements to study how network topologies and cell-to-cell protein abundance v...

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Detalles Bibliográficos
Autores principales: Birtwistle, Marc R, Rauch, Jens, Kiyatkin, Anatoly, Aksamitiene, Edita, Dobrzyński, Maciej, Hoek, Jan B, Kolch, Walter, Ogunnaike, Babatunde A, Kholodenko, Boris N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484110/
https://www.ncbi.nlm.nih.gov/pubmed/22920937
http://dx.doi.org/10.1186/1752-0509-6-109

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