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Functional Lung Imaging during HFV in Preterm Rabbits

Although high frequency ventilation (HFV) is an effective mode of ventilation, there is limited information available in regard to lung dynamics during HFV. To improve the knowledge of lung function during HFV we have developed a novel lung imaging and analysis technique. The technique can determine...

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Autores principales: Thurgood, Jordan, Hooper, Stuart, Siew, Melissa, Wallace, Megan, Dubsky, Stephen, Kitchen, Marcus, Jamison, R. Aidan, Carnibella, Richard, Fouras, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484156/
https://www.ncbi.nlm.nih.gov/pubmed/23118938
http://dx.doi.org/10.1371/journal.pone.0048122
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author Thurgood, Jordan
Hooper, Stuart
Siew, Melissa
Wallace, Megan
Dubsky, Stephen
Kitchen, Marcus
Jamison, R. Aidan
Carnibella, Richard
Fouras, Andreas
author_facet Thurgood, Jordan
Hooper, Stuart
Siew, Melissa
Wallace, Megan
Dubsky, Stephen
Kitchen, Marcus
Jamison, R. Aidan
Carnibella, Richard
Fouras, Andreas
author_sort Thurgood, Jordan
collection PubMed
description Although high frequency ventilation (HFV) is an effective mode of ventilation, there is limited information available in regard to lung dynamics during HFV. To improve the knowledge of lung function during HFV we have developed a novel lung imaging and analysis technique. The technique can determine complex lung motion information in vivo with a temporal resolution capable of observing HFV dynamics. Using high-speed synchrotron based phase contrast X-ray imaging and cross-correlation analysis, this method is capable of recording data in more than 60 independent regions across a preterm rabbit lung in excess of 300 frames per second (fps). This technique is utilised to determine regional intra-breath lung mechanics of preterm rabbit pups during HFV. Whilst ventilated at fixed pressures, each animal was ventilated at frequencies of 1, 3, 5 and 10 Hz. A 50% decrease in delivered tidal volume was measured at 10 Hz compared to 1 Hz, yet at the higher frequency a 500% increase in minute activity was measured. Additionally, HFV induced greater homogeneity of lung expansion activity suggesting this ventilation strategy potentially minimizes tissue damage and improves gas mixing. The development of this technique permits greater insight and further research into lung mechanics and may have implications for the improvement of ventilation strategies used to support severe pulmonary trauma and disease.
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spelling pubmed-34841562012-11-01 Functional Lung Imaging during HFV in Preterm Rabbits Thurgood, Jordan Hooper, Stuart Siew, Melissa Wallace, Megan Dubsky, Stephen Kitchen, Marcus Jamison, R. Aidan Carnibella, Richard Fouras, Andreas PLoS One Research Article Although high frequency ventilation (HFV) is an effective mode of ventilation, there is limited information available in regard to lung dynamics during HFV. To improve the knowledge of lung function during HFV we have developed a novel lung imaging and analysis technique. The technique can determine complex lung motion information in vivo with a temporal resolution capable of observing HFV dynamics. Using high-speed synchrotron based phase contrast X-ray imaging and cross-correlation analysis, this method is capable of recording data in more than 60 independent regions across a preterm rabbit lung in excess of 300 frames per second (fps). This technique is utilised to determine regional intra-breath lung mechanics of preterm rabbit pups during HFV. Whilst ventilated at fixed pressures, each animal was ventilated at frequencies of 1, 3, 5 and 10 Hz. A 50% decrease in delivered tidal volume was measured at 10 Hz compared to 1 Hz, yet at the higher frequency a 500% increase in minute activity was measured. Additionally, HFV induced greater homogeneity of lung expansion activity suggesting this ventilation strategy potentially minimizes tissue damage and improves gas mixing. The development of this technique permits greater insight and further research into lung mechanics and may have implications for the improvement of ventilation strategies used to support severe pulmonary trauma and disease. Public Library of Science 2012-10-30 /pmc/articles/PMC3484156/ /pubmed/23118938 http://dx.doi.org/10.1371/journal.pone.0048122 Text en © 2012 Thurgood et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Thurgood, Jordan
Hooper, Stuart
Siew, Melissa
Wallace, Megan
Dubsky, Stephen
Kitchen, Marcus
Jamison, R. Aidan
Carnibella, Richard
Fouras, Andreas
Functional Lung Imaging during HFV in Preterm Rabbits
title Functional Lung Imaging during HFV in Preterm Rabbits
title_full Functional Lung Imaging during HFV in Preterm Rabbits
title_fullStr Functional Lung Imaging during HFV in Preterm Rabbits
title_full_unstemmed Functional Lung Imaging during HFV in Preterm Rabbits
title_short Functional Lung Imaging during HFV in Preterm Rabbits
title_sort functional lung imaging during hfv in preterm rabbits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484156/
https://www.ncbi.nlm.nih.gov/pubmed/23118938
http://dx.doi.org/10.1371/journal.pone.0048122
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