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Copy number variations associated with obesity related traits in African Americans: a joint analysis between GENOA and HyperGEN

Obesity is a highly heritable trait and a growing public health problem. African Americans are a genetically diverse, yet understudied population with a high prevalence of obesity (body mass index (BMI) greater than 30 kg/m(2)). Recent studies based upon single nucleotide polymorphisms (SNPs) have i...

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Detalles Bibliográficos
Autores principales: Zhao, Wei, Wineinger, Nathan E., Tiwari, Hemant K., Mosley, Thomas H., Broeckel, Ulrich, Arnett, Donna K., Kardia, Sharon L. R., Kabagambe, Edmond K., Sun, Yan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484176/
https://www.ncbi.nlm.nih.gov/pubmed/22836685
http://dx.doi.org/10.1038/oby.2012.162
Descripción
Sumario:Obesity is a highly heritable trait and a growing public health problem. African Americans are a genetically diverse, yet understudied population with a high prevalence of obesity (body mass index (BMI) greater than 30 kg/m(2)). Recent studies based upon single nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome-wide association study of BMI in two African American cohorts from GENOA and HyperGEN. We performed independent and identical association analyses in each study, then combined the results in a meta-analysis. We identified three CNVs associated with BMI, obesity, and other obesity-related traits after adjusting for multiple testing. These CNVs overlap the PARK2, GYPA and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in African Americans.