Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells

Breast cancer is commonly treated with anti-estrogens or aromatase inhibitors, but resistant disease eventually develops and new therapies for such resistance are of great interest. We have previously isolated several tamoxifen-resistant variant sub-lines of the MCF-7 breast cancer cell line and pro...

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Detalles Bibliográficos
Autores principales: Leung, Euphemia, Rewcastle, Gordon W., Joseph, Wayne R., Rosengren, Rhonda J., Larsen, Lesley, Baguley, Bruce C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484282/
https://www.ncbi.nlm.nih.gov/pubmed/22105790
http://dx.doi.org/10.1007/s10637-011-9768-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484282/
https://www.ncbi.nlm.nih.gov/pubmed/22105790
http://dx.doi.org/10.1007/s10637-011-9768-4

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