The role of cGMP signalling in regulating life cycle progression of Plasmodium

The 3′-5′-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium b...

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Detalles Bibliográficos
Autores principales: Hopp, Christine S., Bowyer, Paul W., Baker, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484397/
https://www.ncbi.nlm.nih.gov/pubmed/22613210
http://dx.doi.org/10.1016/j.micinf.2012.04.011
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author Hopp, Christine S.
Bowyer, Paul W.
Baker, David A.
author_facet Hopp, Christine S.
Bowyer, Paul W.
Baker, David A.
author_sort Hopp, Christine S.
collection PubMed
description The 3′-5′-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development. The current views on potential effector proteins downstream of PKG and the mechanisms that may regulate cyclic nucleotide levels are presented.
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spelling pubmed-34843972012-11-14 The role of cGMP signalling in regulating life cycle progression of Plasmodium Hopp, Christine S. Bowyer, Paul W. Baker, David A. Microbes Infect Article The 3′-5′-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development. The current views on potential effector proteins downstream of PKG and the mechanisms that may regulate cyclic nucleotide levels are presented. Elsevier 2012-08 /pmc/articles/PMC3484397/ /pubmed/22613210 http://dx.doi.org/10.1016/j.micinf.2012.04.011 Text en © 2012 Elsevier Masson SAS. https://creativecommons.org/licenses/by/4.0/ Open Access under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) license
spellingShingle Article
Hopp, Christine S.
Bowyer, Paul W.
Baker, David A.
The role of cGMP signalling in regulating life cycle progression of Plasmodium
title The role of cGMP signalling in regulating life cycle progression of Plasmodium
title_full The role of cGMP signalling in regulating life cycle progression of Plasmodium
title_fullStr The role of cGMP signalling in regulating life cycle progression of Plasmodium
title_full_unstemmed The role of cGMP signalling in regulating life cycle progression of Plasmodium
title_short The role of cGMP signalling in regulating life cycle progression of Plasmodium
title_sort role of cgmp signalling in regulating life cycle progression of plasmodium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484397/
https://www.ncbi.nlm.nih.gov/pubmed/22613210
http://dx.doi.org/10.1016/j.micinf.2012.04.011
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