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Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant

Rhodomyrtus tomentosa (Myrtaceae) has been employed in traditional Thai medicine to treat colic diarrhoea, dysentery, abscesses, haemorrhage, and gynaecopathy. In addition, it has been used to formulate skin-whitening, anti-aging and skin beautifying agents. Ethnomedical activities of this plant may...

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Autores principales: Lavanya, Goodla, Voravuthikunchai, Supayang Piyawan, Towatana, Nongporn Hutadilok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484404/
https://www.ncbi.nlm.nih.gov/pubmed/23125869
http://dx.doi.org/10.1155/2012/535479
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author Lavanya, Goodla
Voravuthikunchai, Supayang Piyawan
Towatana, Nongporn Hutadilok
author_facet Lavanya, Goodla
Voravuthikunchai, Supayang Piyawan
Towatana, Nongporn Hutadilok
author_sort Lavanya, Goodla
collection PubMed
description Rhodomyrtus tomentosa (Myrtaceae) has been employed in traditional Thai medicine to treat colic diarrhoea, dysentery, abscesses, haemorrhage, and gynaecopathy. In addition, it has been used to formulate skin-whitening, anti-aging and skin beautifying agents. Ethnomedical activities of this plant may be due its antioxidant property. Hence, the aim of this study was to evaluate both in vitro and in vivo antioxidant activities of R. tomentosa leaf extract. In vitro antioxidant activity of the extract was assessed by lipid peroxidation inhibition capacity, ferric reducing antioxidant power, and metal chelating activity. R. tomentosa extract demonstrated its free radical scavenging effects in concentration dependent manner. In vivo antioxidant activity of the extract was conducted in Swiss Albino mice. Levels of thio-barbituric acid reactive substances (TBARS), glutathione (GSH), and the activities of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in blood, liver, and kidney were analyzed using microtitre plate photometer. Administration of CCl(4) caused significant increase in TBARS and decrease in GSH, SOD, CAT and GPx levels. In contrast, R. tomentosa extract (0.8 g/kg) effectively prevented these alterations and maintained the antioxidant status. The results suggest that R. tomentosa extract can serve as a potent antioxidant.
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spelling pubmed-34844042012-11-02 Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant Lavanya, Goodla Voravuthikunchai, Supayang Piyawan Towatana, Nongporn Hutadilok Evid Based Complement Alternat Med Research Article Rhodomyrtus tomentosa (Myrtaceae) has been employed in traditional Thai medicine to treat colic diarrhoea, dysentery, abscesses, haemorrhage, and gynaecopathy. In addition, it has been used to formulate skin-whitening, anti-aging and skin beautifying agents. Ethnomedical activities of this plant may be due its antioxidant property. Hence, the aim of this study was to evaluate both in vitro and in vivo antioxidant activities of R. tomentosa leaf extract. In vitro antioxidant activity of the extract was assessed by lipid peroxidation inhibition capacity, ferric reducing antioxidant power, and metal chelating activity. R. tomentosa extract demonstrated its free radical scavenging effects in concentration dependent manner. In vivo antioxidant activity of the extract was conducted in Swiss Albino mice. Levels of thio-barbituric acid reactive substances (TBARS), glutathione (GSH), and the activities of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in blood, liver, and kidney were analyzed using microtitre plate photometer. Administration of CCl(4) caused significant increase in TBARS and decrease in GSH, SOD, CAT and GPx levels. In contrast, R. tomentosa extract (0.8 g/kg) effectively prevented these alterations and maintained the antioxidant status. The results suggest that R. tomentosa extract can serve as a potent antioxidant. Hindawi Publishing Corporation 2012 2012-10-18 /pmc/articles/PMC3484404/ /pubmed/23125869 http://dx.doi.org/10.1155/2012/535479 Text en Copyright © 2012 Goodla Lavanya et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lavanya, Goodla
Voravuthikunchai, Supayang Piyawan
Towatana, Nongporn Hutadilok
Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant
title Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant
title_full Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant
title_fullStr Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant
title_full_unstemmed Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant
title_short Acetone Extract from Rhodomyrtus tomentosa: A Potent Natural Antioxidant
title_sort acetone extract from rhodomyrtus tomentosa: a potent natural antioxidant
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484404/
https://www.ncbi.nlm.nih.gov/pubmed/23125869
http://dx.doi.org/10.1155/2012/535479
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