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Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population

PURPOSE: Obesity is a disease with genetic susceptibility characterized by an increase in storage and irregular distribution of body fat. In obese patients, the decrease in the Adiponectin gene (ADIPOQ) expression has been associated with a systemic low-grade inflammatory state. Our aim was to inves...

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Autores principales: Guzman-Ornelas, Milton-Omar, Chavarria-Avila, Efrain, Munoz-Valle, Jose-Francisco, Armas-Ramos, Laura-Elizabeth, Castro-Albarran, Jorge, Aldrete, Maria Elena Aguilar, Oregon-Romero, Edith, Mercado, Monica Vazquez-Del, Navarro-Hernandez, Rosa-Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484511/
https://www.ncbi.nlm.nih.gov/pubmed/23118546
http://dx.doi.org/10.2147/DMSO.S35434
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author Guzman-Ornelas, Milton-Omar
Chavarria-Avila, Efrain
Munoz-Valle, Jose-Francisco
Armas-Ramos, Laura-Elizabeth
Castro-Albarran, Jorge
Aldrete, Maria Elena Aguilar
Oregon-Romero, Edith
Mercado, Monica Vazquez-Del
Navarro-Hernandez, Rosa-Elena
author_facet Guzman-Ornelas, Milton-Omar
Chavarria-Avila, Efrain
Munoz-Valle, Jose-Francisco
Armas-Ramos, Laura-Elizabeth
Castro-Albarran, Jorge
Aldrete, Maria Elena Aguilar
Oregon-Romero, Edith
Mercado, Monica Vazquez-Del
Navarro-Hernandez, Rosa-Elena
author_sort Guzman-Ornelas, Milton-Omar
collection PubMed
description PURPOSE: Obesity is a disease with genetic susceptibility characterized by an increase in storage and irregular distribution of body fat. In obese patients, the decrease in the Adiponectin gene (ADIPOQ) expression has been associated with a systemic low-grade inflammatory state. Our aim was to investigate the relationship between ADIPOQ +45T>G gene simple nucleotide polymorphism (SNP rs2241766) with serum adiponectin (sAdiponectin), distribution of body fat storage, and inflammation markers. SUBJECTS AND METHODS: In this cross-sectional study, 242 individuals from Western Mexico characterized as Mexican-Mestizo and classified by body mass index (BMI), were included. Anthropometrics, body composition, body fat distribution, and inflammation markers were measured by routine methods. Genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and sAdiponectin by the ELISA method. A P-value <0.05 was considered the statistically significant threshold. RESULTS: sAdiponectin is associated with BMI (P < 0.001) and the genotypes (P < 0.001 to 0.0046) GG (8169 ± 1162 ng/mL), TG (5189 ± 501 ng/mL), and TT (3741 ± 323 ng/mL), but the SNP ADIPOQ +45T>G is not associated with BMI. However, the detailed analysis showed association of this SNP with a pattern of fat distribution and correlations (P < 0.05) with inflammation markers and distribution of body fat storage (Pearson’s r = −0.169 to −0.465) were found. CONCLUSION: In this study, we have suggested that the ADIPOQ +45G allele could be associated with distribution of body fat storage in obesity. On the other hand, as no association was observed between ADIPOQ +45T>G gene polymorphism and obesity, it cannot be concluded that the ADIPOQ +45G allele is responsible for the increase of adiponectin levels.
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spelling pubmed-34845112012-11-01 Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population Guzman-Ornelas, Milton-Omar Chavarria-Avila, Efrain Munoz-Valle, Jose-Francisco Armas-Ramos, Laura-Elizabeth Castro-Albarran, Jorge Aldrete, Maria Elena Aguilar Oregon-Romero, Edith Mercado, Monica Vazquez-Del Navarro-Hernandez, Rosa-Elena Diabetes Metab Syndr Obes Original Research PURPOSE: Obesity is a disease with genetic susceptibility characterized by an increase in storage and irregular distribution of body fat. In obese patients, the decrease in the Adiponectin gene (ADIPOQ) expression has been associated with a systemic low-grade inflammatory state. Our aim was to investigate the relationship between ADIPOQ +45T>G gene simple nucleotide polymorphism (SNP rs2241766) with serum adiponectin (sAdiponectin), distribution of body fat storage, and inflammation markers. SUBJECTS AND METHODS: In this cross-sectional study, 242 individuals from Western Mexico characterized as Mexican-Mestizo and classified by body mass index (BMI), were included. Anthropometrics, body composition, body fat distribution, and inflammation markers were measured by routine methods. Genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and sAdiponectin by the ELISA method. A P-value <0.05 was considered the statistically significant threshold. RESULTS: sAdiponectin is associated with BMI (P < 0.001) and the genotypes (P < 0.001 to 0.0046) GG (8169 ± 1162 ng/mL), TG (5189 ± 501 ng/mL), and TT (3741 ± 323 ng/mL), but the SNP ADIPOQ +45T>G is not associated with BMI. However, the detailed analysis showed association of this SNP with a pattern of fat distribution and correlations (P < 0.05) with inflammation markers and distribution of body fat storage (Pearson’s r = −0.169 to −0.465) were found. CONCLUSION: In this study, we have suggested that the ADIPOQ +45G allele could be associated with distribution of body fat storage in obesity. On the other hand, as no association was observed between ADIPOQ +45T>G gene polymorphism and obesity, it cannot be concluded that the ADIPOQ +45G allele is responsible for the increase of adiponectin levels. Dove Medical Press 2012-10-17 /pmc/articles/PMC3484511/ /pubmed/23118546 http://dx.doi.org/10.2147/DMSO.S35434 Text en © 2012 Guzman-Ornelas et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Guzman-Ornelas, Milton-Omar
Chavarria-Avila, Efrain
Munoz-Valle, Jose-Francisco
Armas-Ramos, Laura-Elizabeth
Castro-Albarran, Jorge
Aldrete, Maria Elena Aguilar
Oregon-Romero, Edith
Mercado, Monica Vazquez-Del
Navarro-Hernandez, Rosa-Elena
Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
title Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
title_full Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
title_fullStr Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
title_full_unstemmed Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
title_short Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
title_sort association of adipoq +45t>g polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a mexican-mestizo population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484511/
https://www.ncbi.nlm.nih.gov/pubmed/23118546
http://dx.doi.org/10.2147/DMSO.S35434
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