CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model

Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the inhibitory function of CTLA-4 may be attractive in settings of undesirable T cell respon...

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Detalles Bibliográficos
Autores principales: Yoo, Jong-Sun, Lee, Yun-Jung, Yoon, Joo Won, Hyung, Kyeong Eun, Hwang, Kwang Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484521/
https://www.ncbi.nlm.nih.gov/pubmed/23118560
http://dx.doi.org/10.4196/kjpp.2012.16.5.349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484521/
https://www.ncbi.nlm.nih.gov/pubmed/23118560
http://dx.doi.org/10.4196/kjpp.2012.16.5.349

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