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Cytokines in the systemic inflammatory response syndrome: a review
INTRODUCTION: Patients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the lo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
EDIMES Edizioni Internazionali Srl
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484588/ https://www.ncbi.nlm.nih.gov/pubmed/23441054 |
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author | Jaffer, U Wade, R G Gourlay, T |
author_facet | Jaffer, U Wade, R G Gourlay, T |
author_sort | Jaffer, U |
collection | PubMed |
description | INTRODUCTION: Patients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the loss of local control of the release of these cytokines leads to systemic inflammation and potentially deleterious consequences including the Systemic Inflammatory Response Syndrome, Multi-Organ Dysfunction Syndrome, shock and death. METHODS: The Medline database was searched for literature on mechanisms involved in the development of SIRS and potential targets for modifying the inflammatory response. We focus on the novel therapy of cytokine adsorption as a promising removal technology. RESULTS: Accumulating data from human studies and experimental animal models suggests that both pro- and anti- inflammatory cytokines are released following a variety of initiating stimuli including endotoxin release, complement activation, ischaemia reperfusion injury and others. DISCUSSION: Pro-and anti-inflammatory cytokines interact in a complex and unpredictable manner to influence the immune system and eventually cause multiple end organ effects. Cytokine adsorption therapy provides a potential solution to improving outcomes following Systemic Inflammatory Response Syndrome. |
format | Online Article Text |
id | pubmed-3484588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | EDIMES Edizioni Internazionali Srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-34845882013-02-25 Cytokines in the systemic inflammatory response syndrome: a review Jaffer, U Wade, R G Gourlay, T HSR Proc Intensive Care Cardiovasc Anesth Review-Article INTRODUCTION: Patients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the loss of local control of the release of these cytokines leads to systemic inflammation and potentially deleterious consequences including the Systemic Inflammatory Response Syndrome, Multi-Organ Dysfunction Syndrome, shock and death. METHODS: The Medline database was searched for literature on mechanisms involved in the development of SIRS and potential targets for modifying the inflammatory response. We focus on the novel therapy of cytokine adsorption as a promising removal technology. RESULTS: Accumulating data from human studies and experimental animal models suggests that both pro- and anti- inflammatory cytokines are released following a variety of initiating stimuli including endotoxin release, complement activation, ischaemia reperfusion injury and others. DISCUSSION: Pro-and anti-inflammatory cytokines interact in a complex and unpredictable manner to influence the immune system and eventually cause multiple end organ effects. Cytokine adsorption therapy provides a potential solution to improving outcomes following Systemic Inflammatory Response Syndrome. EDIMES Edizioni Internazionali Srl 2010 /pmc/articles/PMC3484588/ /pubmed/23441054 Text en Copyright © 2010, HSR Proceedings in Intensive Care and Cardiovascular Anesthesia http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License 3.0, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode. |
spellingShingle | Review-Article Jaffer, U Wade, R G Gourlay, T Cytokines in the systemic inflammatory response syndrome: a review |
title | Cytokines in the systemic inflammatory response syndrome: a review |
title_full | Cytokines in the systemic inflammatory response syndrome: a review |
title_fullStr | Cytokines in the systemic inflammatory response syndrome: a review |
title_full_unstemmed | Cytokines in the systemic inflammatory response syndrome: a review |
title_short | Cytokines in the systemic inflammatory response syndrome: a review |
title_sort | cytokines in the systemic inflammatory response syndrome: a review |
topic | Review-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484588/ https://www.ncbi.nlm.nih.gov/pubmed/23441054 |
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