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Volatile anaesthetic myocardial protection: a review of the current literature
Ischaemic preconditioning is a powerful innate adaptive phenomenon whereby brief periods of sublethal ischaemia result in marked tolerance to subsequent lethal ischaemia. Halogenated anaesthetics have been shown to mimic ischaemic preconditioning, modifying and attenuating ischaemia reperfusion inju...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
EDIMES Edizioni Internazionali Srl
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484611/ https://www.ncbi.nlm.nih.gov/pubmed/23440181 |
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author | Lin, E Symons, J A |
author_facet | Lin, E Symons, J A |
author_sort | Lin, E |
collection | PubMed |
description | Ischaemic preconditioning is a powerful innate adaptive phenomenon whereby brief periods of sublethal ischaemia result in marked tolerance to subsequent lethal ischaemia. Halogenated anaesthetics have been shown to mimic ischaemic preconditioning, modifying and attenuating ischaemia reperfusion injury. This review aims to present the current animal and human data, discuss the possible mechanisms of action and review the clinical evidence for volatile anaesthetic-induced myocardial protection. There is class Ia evidence for the myocardial protective properties of sevoflurane and desflurane in low risk patients undergoing coronary artery bypass grafting surgery. These volatile anaesthetics have been shown to improve clinical outcomes and health economics following cardiac surgery, reducing intensive care and hospital stay. The evidence for the benefit of volatile anaesthetics in non-cardiac surgery is less robust and further large randomized controlled trials are required to elucidate this question. |
format | Online Article Text |
id | pubmed-3484611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | EDIMES Edizioni Internazionali Srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-34846112013-02-25 Volatile anaesthetic myocardial protection: a review of the current literature Lin, E Symons, J A HSR Proc Intensive Care Cardiovasc Anesth Brief-Report Ischaemic preconditioning is a powerful innate adaptive phenomenon whereby brief periods of sublethal ischaemia result in marked tolerance to subsequent lethal ischaemia. Halogenated anaesthetics have been shown to mimic ischaemic preconditioning, modifying and attenuating ischaemia reperfusion injury. This review aims to present the current animal and human data, discuss the possible mechanisms of action and review the clinical evidence for volatile anaesthetic-induced myocardial protection. There is class Ia evidence for the myocardial protective properties of sevoflurane and desflurane in low risk patients undergoing coronary artery bypass grafting surgery. These volatile anaesthetics have been shown to improve clinical outcomes and health economics following cardiac surgery, reducing intensive care and hospital stay. The evidence for the benefit of volatile anaesthetics in non-cardiac surgery is less robust and further large randomized controlled trials are required to elucidate this question. EDIMES Edizioni Internazionali Srl 2010 /pmc/articles/PMC3484611/ /pubmed/23440181 Text en Copyright © 2010, HSR Proceedings in Intensive Care and Cardiovascular Anesthesia http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License 3.0, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode. |
spellingShingle | Brief-Report Lin, E Symons, J A Volatile anaesthetic myocardial protection: a review of the current literature |
title | Volatile anaesthetic myocardial protection: a review of the current literature |
title_full | Volatile anaesthetic myocardial protection: a review of the current literature |
title_fullStr | Volatile anaesthetic myocardial protection: a review of the current literature |
title_full_unstemmed | Volatile anaesthetic myocardial protection: a review of the current literature |
title_short | Volatile anaesthetic myocardial protection: a review of the current literature |
title_sort | volatile anaesthetic myocardial protection: a review of the current literature |
topic | Brief-Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484611/ https://www.ncbi.nlm.nih.gov/pubmed/23440181 |
work_keys_str_mv | AT line volatileanaestheticmyocardialprotectionareviewofthecurrentliterature AT symonsja volatileanaestheticmyocardialprotectionareviewofthecurrentliterature |