Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit

We report the case of a 34-year-old woman affected by breast cancer that had metastasized to the bone. She had been treated with oral cyclophosphamide and methotrexate (metronomic chemotherapy) and achieved 3.5 years of clinical remission. To our knowledge, this is the first description of such a pr...

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Detalles Bibliográficos
Autores principales: Masci, G, Losurdo, A, Gandini, C, Garassino, I, di Tommaso, L, Torrisi, R, Zuradelli, M, Santoro, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484813/
https://www.ncbi.nlm.nih.gov/pubmed/23130087
http://dx.doi.org/10.3332/ecancer.2012.275
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author Masci, G
Losurdo, A
Gandini, C
Garassino, I
di Tommaso, L
Torrisi, R
Zuradelli, M
Santoro, A
author_facet Masci, G
Losurdo, A
Gandini, C
Garassino, I
di Tommaso, L
Torrisi, R
Zuradelli, M
Santoro, A
author_sort Masci, G
collection PubMed
description We report the case of a 34-year-old woman affected by breast cancer that had metastasized to the bone. She had been treated with oral cyclophosphamide and methotrexate (metronomic chemotherapy) and achieved 3.5 years of clinical remission. To our knowledge, this is the first description of such a prolonged response to therapy. This case report adds weight to known data on metronomic treatment and supports further investigation of this therapy.
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spelling pubmed-34848132012-11-05 Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit Masci, G Losurdo, A Gandini, C Garassino, I di Tommaso, L Torrisi, R Zuradelli, M Santoro, A Ecancermedicalscience Case Report We report the case of a 34-year-old woman affected by breast cancer that had metastasized to the bone. She had been treated with oral cyclophosphamide and methotrexate (metronomic chemotherapy) and achieved 3.5 years of clinical remission. To our knowledge, this is the first description of such a prolonged response to therapy. This case report adds weight to known data on metronomic treatment and supports further investigation of this therapy. Cancer Intelligence 2012-10-18 /pmc/articles/PMC3484813/ /pubmed/23130087 http://dx.doi.org/10.3332/ecancer.2012.275 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Masci, G
Losurdo, A
Gandini, C
Garassino, I
di Tommaso, L
Torrisi, R
Zuradelli, M
Santoro, A
Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
title Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
title_full Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
title_fullStr Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
title_full_unstemmed Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
title_short Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
title_sort low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484813/
https://www.ncbi.nlm.nih.gov/pubmed/23130087
http://dx.doi.org/10.3332/ecancer.2012.275
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