Leukocyte ABCA1 Remains Atheroprotective in Splenectomized LDL Receptor Knockout Mice

AIM: ATP-binding cassette transporter A1 (ABCA1) is an important mediator of macrophage cholesterol efflux. It mediates the efflux of cellular cholesterol to lipid-poor apolipoprotein A-I. LDL receptor (LDLr) knockout (KO) mice deficient for leukocyte ABCA1 (ABCA1 KO→LDLr KO) show increased atherosc...

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Detalles Bibliográficos
Autores principales: Lammers, Bart, Zhao, Ying, Foks, Amanda C., Hildebrand, Reeni B., Kuiper, Johan, Van Berkel, Theo J. C., Van Eck, Miranda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485037/
https://www.ncbi.nlm.nih.gov/pubmed/23133551
http://dx.doi.org/10.1371/journal.pone.0048080

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