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Role of Disulfide Cross-Linking of Mutant SOD1 in the Formation of Inclusion-Body-Like Structures

BACKGROUND: Pathologic aggregates of superoxide dismutase 1 (SOD1) harboring mutations linked to familial amyotrophic lateral sclerosis (fALS) have been shown to contain aberrant intermolecular disulfide cross-links. In prior studies, we observed that intermolecular bonding was not necessary in the...

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Detalles Bibliográficos
Autores principales:	Roberts, Brittany L. T., Patel, Kinaree, Brown, Hilda H., Borchelt, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485248/ https://www.ncbi.nlm.nih.gov/pubmed/23118898 http://dx.doi.org/10.1371/journal.pone.0047838

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