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Everolimus and Sirolimus in Combination with Cyclosporine Have Different Effects on Renal Metabolism in the Rat

Enhancement of calcineurin inhibitor nephrotoxicity by sirolimus (SRL) is limiting the clinical use of this drug combination. We compared the dose-dependent effects of the structurally related everolimus (EVL) and sirolimus (SRL) alone, and in combination with cyclosporine (CsA), on the rat kidney....

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Detalles Bibliográficos
Autores principales:	Bohra, Rahul, Schöning, Wenzel, Klawitter, Jelena, Brunner, Nina, Schmitz, Volker, Shokati, Touraj, Lawrence, Ryan, Arbelaez, Maria Fernanda, Schniedewind, Björn, Christians, Uwe, Klawitter, Jost
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485290/ https://www.ncbi.nlm.nih.gov/pubmed/23118926 http://dx.doi.org/10.1371/journal.pone.0048063

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