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Deletion of the Viral Anti-Apoptotic Gene F1L in the HIV/AIDS Vaccine Candidate MVA-C Enhances Immune Responses against HIV-1 Antigens

Vaccinia virus (VACV) encodes an anti-apoptotic Bcl-2-like protein F1 that acts as an inhibitor of caspase-9 and of the Bak/Bax checkpoint but the role of this gene in immune responses is not known. Because dendritic cells that have phagocytosed apoptotic infected cells cross-present viral antigens...

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Detalles Bibliográficos
Autores principales:	Perdiguero, Beatriz, Gómez, Carmen Elena, Nájera, Jose Luis, Sorzano, Carlos Oscar S., Delaloye, Julie, González-Sanz, Rubén, Jiménez, Victoria, Roger, Thierry, Calandra, Thierry, Pantaleo, Giuseppe, Esteban, Mariano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485360/ https://www.ncbi.nlm.nih.gov/pubmed/23119046 http://dx.doi.org/10.1371/journal.pone.0048524

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