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The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485540/ https://www.ncbi.nlm.nih.gov/pubmed/23150737 http://dx.doi.org/10.1155/2012/236075 |
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author | Williams, Jesse W. Tjota, Melissa Y. Sperling, Anne I. |
author_facet | Williams, Jesse W. Tjota, Melissa Y. Sperling, Anne I. |
author_sort | Williams, Jesse W. |
collection | PubMed |
description | In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells. Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance. In this paper, we review the literature to help define the nature of IgG and FcγR signaling on innate immune cells and how it contributes to the development of allergic immune responses. |
format | Online Article Text |
id | pubmed-3485540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34855402012-11-13 The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation Williams, Jesse W. Tjota, Melissa Y. Sperling, Anne I. J Allergy (Cairo) Review Article In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells. Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance. In this paper, we review the literature to help define the nature of IgG and FcγR signaling on innate immune cells and how it contributes to the development of allergic immune responses. Hindawi Publishing Corporation 2012 2012-10-21 /pmc/articles/PMC3485540/ /pubmed/23150737 http://dx.doi.org/10.1155/2012/236075 Text en Copyright © 2012 Jesse W. Williams et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Williams, Jesse W. Tjota, Melissa Y. Sperling, Anne I. The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation |
title | The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation |
title_full | The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation |
title_fullStr | The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation |
title_full_unstemmed | The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation |
title_short | The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation |
title_sort | contribution of allergen-specific igg to the development of th2-mediated airway inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485540/ https://www.ncbi.nlm.nih.gov/pubmed/23150737 http://dx.doi.org/10.1155/2012/236075 |
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