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The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation

In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation....

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Detalles Bibliográficos
Autores principales: Williams, Jesse W., Tjota, Melissa Y., Sperling, Anne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485540/
https://www.ncbi.nlm.nih.gov/pubmed/23150737
http://dx.doi.org/10.1155/2012/236075
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author Williams, Jesse W.
Tjota, Melissa Y.
Sperling, Anne I.
author_facet Williams, Jesse W.
Tjota, Melissa Y.
Sperling, Anne I.
author_sort Williams, Jesse W.
collection PubMed
description In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells. Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance. In this paper, we review the literature to help define the nature of IgG and FcγR signaling on innate immune cells and how it contributes to the development of allergic immune responses.
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spelling pubmed-34855402012-11-13 The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation Williams, Jesse W. Tjota, Melissa Y. Sperling, Anne I. J Allergy (Cairo) Review Article In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells. Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance. In this paper, we review the literature to help define the nature of IgG and FcγR signaling on innate immune cells and how it contributes to the development of allergic immune responses. Hindawi Publishing Corporation 2012 2012-10-21 /pmc/articles/PMC3485540/ /pubmed/23150737 http://dx.doi.org/10.1155/2012/236075 Text en Copyright © 2012 Jesse W. Williams et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Williams, Jesse W.
Tjota, Melissa Y.
Sperling, Anne I.
The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
title The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
title_full The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
title_fullStr The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
title_full_unstemmed The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
title_short The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
title_sort contribution of allergen-specific igg to the development of th2-mediated airway inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485540/
https://www.ncbi.nlm.nih.gov/pubmed/23150737
http://dx.doi.org/10.1155/2012/236075
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