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Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis

BACKGROUND: Many growth factors, such as bone morphogenetic protein (BMP)-2, have been shown to interact with polymers of sulfated disacharrides known as heparan sulfate (HS) glycosaminoglycans (GAGs), which are found on matrix and cell-surface proteoglycans throughout the body. HS GAGs, and some mo...

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Detalles Bibliográficos
Autores principales:	DeCarlo, Arthur A, Belousova, Maria, Ellis, April L, Petersen, Donald, Grenett, Hernan, Hardigan, Patrick, O’Grady, Robert, Lord, Megan, Whitelock, John M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485628/ https://www.ncbi.nlm.nih.gov/pubmed/22967000 http://dx.doi.org/10.1186/1472-6750-12-60

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