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Novel olanzapine analogues presenting a reduced H(1) receptor affinity and retained 5HT(2A)/D(2) binding affinity ratio

BACKGROUND: Olanzapine is an atypical antipsychotic drug with high clinical efficacy, but which can cause severe weight gain and metabolic disorders in treated patients. Blockade of the histamine 1 (H(1)) receptors is believed to play a crucial role in olanzapine induced weight gain, whereas the the...

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Detalles Bibliográficos
Autores principales:	Jafari, Somayeh, Bouillon, Marc E, Huang, Xu-Feng, Pyne, Stephen G, Fernandez-Enright, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485633/ https://www.ncbi.nlm.nih.gov/pubmed/22726212 http://dx.doi.org/10.1186/1471-2210-12-8

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